Mouse Ectodysplasin-A ELISA Kit | Eda elisa kit

Mouse Ectodysplasin-A ELISA Kit

Cat. Num. AAA2882291

• Gene Names: Eda; Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2; Tnlg7c
• Reactivity: Mouse
• Synonyms: Ectodysplasin-A; Mouse Ectodysplasin-A ELISA Kit; EDA protein homolog; Tabby protein; Eda; Ed1; Ta; Eda elisa kit

• Reactivity: Mouse
• Sequence Length: 389

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.091 ng/mL
• Intra-Assay CV: <=6.9%
• Inter-Assay CV: <=8.8%
• Recovery: 102%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 295789018
• NCBI GeneID: 13607
• NCBI Accession #: NP_001171408.1
• NCBI GenBank Nucleotide #: NM_001177937.1
• UniProt Accession #: O54693; O35705; Q9QWJ8; Q9QZ01; Q9QZ02; B7ZMT7
• Molecular Weight: 39,988 Da
• NCBI Official Full Name: ectodysplasin-A isoform 2
• NCBI Official Synonym Full Names: ectodysplasin-A
• NCBI Official Symbol: Eda
• NCBI Official Synonym Symbols: Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2; Tnlg7c
• NCBI Protein Information: ectodysplasin-A
• UniProt Protein Name: Ectodysplasin-A
• Protein Family: Ectodysplasin
• UniProt Gene Name: Eda
• UniProt Synonym Gene Names: Ed1; Ta
• UniProt Entry Name: EDA_MOUSE

Uniprot Description

EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: apical part of cell; collagen; endoplasmic reticulum membrane; extracellular region; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: tumor necrosis factor receptor binding

Biological Process: cell differentiation; cell-matrix adhesion; gene expression; hair follicle development; immune response; multicellular organismal development; odontogenesis of dentine-containing teeth; pigmentation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB import into nucleus; skin development