Rabbit Extracellular Matrix Protein 1 ELISA Kit | ECM1 elisa kit

Rabbit Extracellular Matrix Protein 1 ELISA Kit

Cat. Num. AAA721197

• Reactivity: Rabbit
• Synonyms: Extracellular Matrix Protein 1; Rabbit Extracellular Matrix Protein 1 ELISA Kit; ECM1 elisa kit

• Reactivity: Rabbit

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 100-2500pg/mL
• Sensitivity: 1.0pg/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for ECM1 elisa kit

Neurobiology

NCBI and Uniprot Product Information

• NCBI GI #: 2654433
• Molecular Weight: 63,563 Da
• NCBI Official Full Name: extracellular matrix protein 1
• UniProt Protein Name: Extracellular matrix protein 1
• Protein Family: Extracellular matrix protein
• UniProt Gene Name: ECM1
• UniProt Entry Name: ECM1_HUMAN

Uniprot Description

ECM1: Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. Defects in ECM1 are the cause of lipoid proteinosis (LiP); also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix

Molecular Function: protein C-terminus binding; protein binding; signal transducer activity; enzyme binding; protease binding; interleukin-2 receptor binding; laminin binding

Biological Process: ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of peptidase activity; signal transduction; regulation of transcription from RNA polymerase II promoter; negative regulation of bone mineralization; positive regulation of angiogenesis; biomineral formation; positive regulation of endothelial cell proliferation; negative regulation of cytokine and chemokine mediated signaling pathway; angiogenesis; inflammatory response; regulation of T-helper 2 type immune response

Disease: Lipoid Proteinosis Of Urbach And Wiethe