Peptidylprolyl Isomerase Active Protein | PPIL2 active protein
Recombinant Human Peptidylprolyl Isomerase (Cyclophilin)-Like 2
Sterile Filtered clear colorless solution.
Introduction: PPIL2 is part of the cyclophilin family of peptidylprolyl isomerases which are highly conserved ubiquitous proteins that play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. PPIL2 increases folding of proteins andcatalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PPIL2: a peptidylprolyl isomerase (PPIase) of the cyclophilin-type family. PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds. Two alternatively-spliced isoforms have been described.
Protein type: Ligase; Cyclophilin; Ubiquitin conjugating system; EC 5.2.1.8; Spliceosome; Ubiquitin ligase; Isomerase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: nucleoplasm; Golgi lumen; cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; ligase activity
Biological Process: protein polyubiquitination; protein peptidyl-prolyl isomerization; protein folding; blood coagulation; leukocyte migration
Research Articles on PPIL2
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Product Notes
The PPIL2 ppil2 (Catalog #AAA144027) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK IIDPDEEKAK QDPSYYLKNT NAETRETLQE YKEFKGDEI LAATMKAPEK KKVDKLNAAH YSTGKVSASF TSTAMVPETT EAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV GKYINPAATE QQRKSPQPVP LSPCPRRSPV GVLGTSAPGS SRLPDDH. It is sometimes possible for the material contained within the vial of "Peptidylprolyl Isomerase, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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