APRIL active protein
Mouse APRIL
Gene Names
Tnfsf13; April; Tall2; Trdl1; 2310026N09Rik
Reactivity
Mouse
Purity
> 98% by SDS-PAGE and HPLC
Synonyms
APRIL; Mouse APRIL; Recombinant Murine APRIL; APRIL active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE and HPLC
Form/Format
Lyophilized
Sequence
MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRR RAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL E AQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFR CIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SP HGTFLGFV KL
Sequence Length
240
Endotoxin Level
< 0.1 ng per ug of APRIL
Biological Activity
Measured by its ability to induce cell proliferation of activated T cells.
Related Product Information for APRIL active protein
APRIL (a proliferation inducing ligand), also known as TNFSF13, TALL2, and TRDL1, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa type II transmembrane protein which is cleaved by furin in the Golgi to release a 17 kDa soluble molecule. Secreted APRIL consists almost entirely of a single TNF homology domain. Little or no transmembrane APRIL is expressed on the cell surface. Alternate splicing generates isoforms with short deletions at the Nor C-terminus. Both APRIL and the closely related protein BAFF signal through the TNF superfamily receptors TACI and BCMA to promote cellular proliferation and protect from apoptosis. APRIL can form bioactive heterotrimers with BAFF. A bioactive cell surface-expressed protein known as TWEPRIL consists of the intracellular domain, transmembrane segment, and stalk region of TWEAK fused to the TNF homology domain of APRIL. Human APRIL shares 85% amino acid sequence identity with mouse and rat APRIL.
Product Categories/Family for APRIL active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21.9 kDa
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 13 isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol
Tnfsf13
NCBI Official Synonym Symbols
April; Tall2; Trdl1; 2310026N09Rik
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Gene Name
Tnfsf13
UniProt Synonym Gene Names
April; APRIL
UniProt Entry Name
TNF13_MOUSE
Uniprot Description
Function: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Ref.4
Subunit structure: Homotrimer
Potential.
Subcellular location: Secreted
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.
Miscellaneous: Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (Ref.4).
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on APRIL
Similar Products
Product Notes
The APRIL tnfsf13 (Catalog #AAA691819) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse APRIL reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRR RAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL E AQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFR CIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SP HGTFLGFV KL. It is sometimes possible for the material contained within the vial of "APRIL, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
