Rabbit anti-Human APRIL Polyclonal Antibody | anti-TNFSF13 antibody

APRIL Antibody

Cat. Num. AAA151402

• Gene Names: TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: APRIL Antibody is affinity chromatography purified via peptide column.
• Synonyms: APRIL; Polyclonal Antibody; APRIL Antibody; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715; Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; tumor necrosis factor (ligand) superfamily; member 13; anti-TNFSF13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: APRIL Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 250

• Applicable Applications for anti-TNFSF13 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: APRIL can be used for detection of APRIL by Western blot at 5 - 10 mug/mL. A 27 kDa band can be detected.
• Conjugate: Unconjugated
• Immunogen: APRIL antibody was raised against a synthetic peptide corresponding to amino acids near the center of human APRIL.
• Buffer: APRIL Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: APRIL antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of APRIL expression in K562 cells with APRIL antibody at (A) 5 and (B) 10 μg/mL.)

Related Product Information for anti-TNFSF13 antibody

APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 4507599
• NCBI GeneID: 8741
• NCBI Accession #: NP_003799
• NCBI GenBank Nucleotide #: NM_003808.3
• UniProt Accession #: O75888; Q541E1; Q5U0G8; Q96HV6; Q9P1M8; Q9P1M9; A8MYD5; B4DVT2
• Molecular Weight: 27 kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 13
• NCBI Official Symbol: TNFSF13
• NCBI Official Synonym Symbols: APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 13
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF13
• UniProt Synonym Gene Names: APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1
• UniProt Entry Name: TNF13_HUMAN

NCBI Description

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Uniprot Description

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol; external side of plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; gene expression; signal transduction; positive regulation of isotype switching to IgA isotypes