Testing Data
APRIL active protein
Murine APRIL
Gene Names
Tnfsf13; April; Tall2; Trdl1; 2310026N09Rik
Reactivity
Species Reactivity: MouseCross Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
APRIL; Murine APRIL; Recombinant Murine APRIL; APRIL active protein
Host
E Coli
Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Cross Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
MRREVSRLQ RSGGPSQKQ GERPWQSLW EQSPDVLEA WKDGAKSRR RRAVLTQKH KKKHSVLHL VPVNITSKD SDVTEVMWQ PVLRRGRGL EAQGDIVRV WDTGIYLLY SQVLFHDVT FTMGQVVSR EGQGRRETL FRCIRSMPS DPDRAYNSC YSAGVFHLH QGDIITVKI PRANAKLSL SPHGTFLGF VKL
Biological Activity
Measured by its ability to induce cell proliferation of activated T cells.
Cell Type
B Cells, Monocytes and Macrophages, T Cells
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for APRIL active protein
APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.
Product Categories/Family for APRIL active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
26,889 Da
NCBI Official Full Name
Tumor necrosis factor ligand superfamily member 13
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol
Tnfsf13
NCBI Official Synonym Symbols
April; Tall2; Trdl1; 2310026N09Rik
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Gene Name
Tnfsf13
UniProt Synonym Gene Names
April; APRIL
UniProt Entry Name
TNF13_MOUSE
Uniprot Description
TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; external side of plasma membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor binding
Biological Process: regulation of immune response; immune system process; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; immune response; immunoglobulin mediated immune response; positive regulation of isotype switching to IgA isotypes
Research Articles on APRIL
Similar Products
Product Notes
The APRIL tnfsf13 (Catalog #AAA695734) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Murine APRIL reacts with Species Reactivity: Mouse Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MRREVSRLQ RSGGPSQKQ GERPWQSLW EQSPDVLEA WKDGAKSRR RRAVLTQKH KKKHSVLHL VPVNITSKD SDVTEVMWQ PVLRRGRGL EAQGDIVRV WDTGIYLLY SQVLFHDVT FTMGQVVSR EGQGRRETL FRCIRSMPS DPDRAYNSC YSAGVFHLH QGDIITVKI PRANAKLSL SPHGTFLGF VKL. It is sometimes possible for the material contained within the vial of "APRIL, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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