Monocyte Chemotactic Protein-2 Active Protein | MCP 2 active protein
Recombinant Canine Monocyte Chemotactic Protein-2 (CCL8)
Gene Names
CCL8; MCP-2
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Synonyms
Monocyte Chemotactic Protein-2; Recombinant Canine Monocyte Chemotactic Protein-2 (CCL8); MCP 2 Canine; C-C motif chemokine 8; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8; CCL8; MCP2; Monocyte Chemotactic Protein-2 Canine Recombinant (CCL8); MCP 2 active protein
Host
E Coli
Purity/Purification
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Form/Format
Sterile filtered white lyophilized (freeze-dried) powder.
MCP-2 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH7.4.
MCP-2 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH7.4.
Sequence
QPDSVSIPIT CCFSMVKRKI PMQKLESYMR ITNSQCPQEA VIFKTKASRE ICADPKQKWV QDYMNHLDQK SQAQKP
Sequence Length
99
Solubility
It is recommended to reconstitute the lyophilized MCP2 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.
Preparation and Storage
Although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for MCP 2 active protein
Description: MCP2 Canine Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8.8kDa. The CCL8 is purified by proprietary chromatographic techniques.
Introduction: Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.
Introduction: Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.
Product Categories/Family for MCP 2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
11,263 Da
NCBI Official Full Name
C-C motif chemokine 8
NCBI Official Symbol
CCL8
NCBI Official Synonym Symbols
MCP-2
NCBI Protein Information
C-C motif chemokine 8
UniProt Protein Name
C-C motif chemokine 8
UniProt Gene Name
CCL8
UniProt Synonym Gene Names
MCP2; MCP-2
Uniprot Description
Chemotactic factor that attracts monocytes. This protein can bind heparin ().
Similar Products
Product Notes
The MCP 2 ccl8 (Catalog #AAA146712) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: QPDSVSIPIT CCFSMVKRKI PMQKLESYMR ITNSQCPQEA VIFKTKASRE ICADPKQKWV QDYMNHLDQK SQAQKP. It is sometimes possible for the material contained within the vial of "Monocyte Chemotactic Protein-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
