MEC (CCL28) Active Protein | MEC active protein

Human MEC (CCL28)

Cat. Num. AAA691608

• Gene Names: CCL28; MEC; CCK1; SCYA28
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analysis
• Synonyms: MEC (CCL28); Human MEC (CCL28); Recombinant Human MEC; MEC active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVIL HVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN S NRAHQGKHE TYGHKTPY
• Sequence Length: 127

• Endotoxin Level: < 0.1 ng per ug of MEC
• Biological Activity: Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-10.0 ng/ml.

Related Product Information for MEC active protein

MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary glad, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Product Categories/Family for MEC active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 22538811
• NCBI GeneID: 56477
• NCBI Accession #: NP_683513.1
• NCBI GenBank Nucleotide #: NM_148672.2
• UniProt Accession #: Q9NRJ3; D7RIE7
• Molecular Weight: 12.3 kDa
• NCBI Official Full Name: C-C motif chemokine 28
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 28
• NCBI Official Symbol: CCL28
• NCBI Official Synonym Symbols: MEC; CCK1; SCYA28
• NCBI Protein Information: C-C motif chemokine 28; CC chemokine CCL28; small inducible cytokine A28; small-inducible cytokine A28; mucosae-associated epithelial chemokine; chemokine (C-C motif) ligand 28 splice variant chi; small inducible cytokine subfamily A (Cys-Cys), member 28
• UniProt Protein Name: C-C motif chemokine 28
• Protein Family: CysO-cysteine peptidase
• UniProt Gene Name: CCL28
• UniProt Synonym Gene Names: SCYA28; MEC
• UniProt Entry Name: CCL28_HUMAN

NCBI Description

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Subcellular location: Secreted.

Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.