FGF-4 active protein

Human FGF-4

Cat. Num. AAA692124

• Gene Names: FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• Reactivity: Human
• Purity: > 95% by SDS-PAGE & silver stain
• Synonyms: FGF-4; Human FGF-4; Recombinant Human FGF-4; HBGF-4; Heparin-binding growth factor 4; Kfgf; FGF-4 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & silver stain
• Form/Format: Lyophilized
• Sequence: N-Terminal Sequence: MAPTAPNGTL
• Sequence Length: 177

• N Terminal Sequence: MAPTAPNGTL
• Buffer: PBS
• Preparation and Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20 degree C. Reconstituted FGF-4 should be stored in working aliquots at -20 degree C. Avoid repeated freeze-thaw cycles.

Testing Data

Testing Data #2

Related Product Information for FGF-4 active protein

FGF-4 (fibroblast growth factor 4), also known as K-FGF (Kaposi's sarcoma associated FGF), is a 25 kDa secreted, heparin binding member of the FGF family. The human FGF-4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C terminus. Mature human FGF-4 shares a high aa identity with mouse, rat, canine and bovine FGF-4, respectively. The expression of FGF-4 and its receptors, FGF-R1c, -R2c, -R3c and R4, is spatially and temporally regulated during embryonic development. Its expression in the mouse trophoblast inner cell mass promotes expression of FGF-R2, and is required for maintenance of the trophectoderm and primitive endoderm. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell self-renewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in-vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in-vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in-vivo and has been investigated as therapy for coronary artery disease.

Product Categories/Family for FGF-4 active protein

Cytokines & Growth Factors

References

1. Feldman B et al, Science 267:246, 1995 2. Sun X et al, Nature 418:501, 2002 3. Mariani FV et al, Nature 453:401, 2008 4. Johannesson M et al, PLoS ONE 4:e4794, 2009 5. Kunath T et al, Development 134:2895, 2007 6. Mayshar Y et al, Stem Cells 26:767, 2008 7. Hajitou A et al, Oncogene 17:2059, 1998

NCBI and Uniprot Product Information

• NCBI GI #: 4503701
• NCBI GeneID: 2249
• NCBI Accession #: NP_001998.1
• NCBI GenBank Nucleotide #: NM_002007
• UniProt Accession #: P08620; B7U994; AAB21430
• Molecular Weight: 19,7 kDa
• NCBI Official Full Name: fibroblast growth factor 4
• NCBI Official Synonym Full Names: fibroblast growth factor 4
• NCBI Official Symbol: FGF4
• NCBI Official Synonym Symbols: HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• NCBI Protein Information: fibroblast growth factor 4; FGF-4; HSTF-1; oncogene HST; kaposi sarcoma oncogene; transforming protein KS3; heparin-binding growth factor 4; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; fibroblast growth factor 4 splice isoform; human stomach cancer, transforming factor from FGF-related oncogene
• UniProt Protein Name: Fibroblast growth factor 4
• UniProt Gene Name: FGF4
• UniProt Synonym Gene Names: HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4
• UniProt Entry Name: FGF4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. Ref.5

Subunit structure: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.5

Subcellular location: Secreted

Potential.

Sequence similarities: Belongs to the heparin-binding growth factors family.