FGF-4 recombinant protein

Recombinant Human FGF-4

Cat. Num. AAA2569117

• Gene Names: FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: FGF-4; Recombinant Human FGF-4; Fibroblast growth factor 4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3; FGF4; HSTF1; KS3 ; FGF-4 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, 5% Trehalose, pH7.4.
• Sequence: Ser71--Leu206

• Species: Human
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Fibroblast Growth Factor 4 is produced by our E Coli expression system and the target gene encoding Ser71-Leu206 is expressed.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for FGF-4 recombinant protein

Fibroblast growth factor 4 (FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.

Product Categories/Family for FGF-4 recombinant protein

Signal Transduction; Cardiovascular; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 4503701
• NCBI GeneID: 2249
• NCBI Accession #: NP_001998.1
• NCBI GenBank Nucleotide #: NM_002007.2
• UniProt Accession #: P08620; B7U994; AAB21430
• Molecular Weight: 12,237 Da
• NCBI Official Full Name: fibroblast growth factor 4
• NCBI Official Synonym Full Names: fibroblast growth factor 4
• NCBI Official Symbol: FGF4
• NCBI Official Synonym Symbols: HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• NCBI Protein Information: fibroblast growth factor 4; FGF-4; HSTF-1; fibroblast growth factor 4 splice isoform; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; heparin-binding growth factor 4; human stomach cancer, transforming factor from FGF-r
• UniProt Protein Name: Fibroblast growth factor 4
• UniProt Gene Name: FGF4
• UniProt Synonym Gene Names: HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4
• UniProt Entry Name: FGF4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.