Eotaxin-3 (CCL26) Active Protein | CCL26 active protein

Human Eotaxin-3 (CCL26)

Cat. Num. AAA691877

• Gene Names: CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analyses
• Synonyms: Eotaxin-3 (CCL26); Human Eotaxin-3 (CCL26); Recombinant Human Eotaxin-3 (TSC); CCL26 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRG KKVC THPRKKWVQK YISLLKTPKQ L
• Sequence Length: 94

• Endotoxin Level: < 0.1 ng per g of Eotaxin-3
• Biological Activity: Determined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2ug/ml.

Related Product Information for CCL26 active protein

Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Product Categories/Family for CCL26 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 5174671
• NCBI GeneID: 10344
• NCBI Accession #: NP_006063.1
• NCBI GenBank Nucleotide #: NM_006072.4
• UniProt Accession #: Q9Y258; Q52LV8; A0N0Q5
• Molecular Weight: 8.4 kDa
• NCBI Official Full Name: C-C motif chemokine 26
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 26
• NCBI Official Symbol: CCL26
• NCBI Official Synonym Symbols: IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
• NCBI Protein Information: C-C motif chemokine 26; eotaxin-3; MIP-4-alpha; chemokine N1; CC chemokine IMAC; thymic stroma chemokine-1; small inducible cytokine A26; small-inducible cytokine A26; macrophage inflammatory protein 4-alpha; small inducible cytokine subfamily A (Cys-Cys), member 26
• UniProt Protein Name: C-C motif chemokine 26
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL26
• UniProt Synonym Gene Names: SCYA26; MIP-4-alpha; TSC-1
• UniProt Entry Name: CCL26_HUMAN

NCBI Description

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Chemotactic for eosinophils and basophils. Binds to CCR3.

Subunit structure: Monomer.

Subcellular location: Secreted.

Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.