4-1BB receptor, soluble (TNFRSF9) Active Protein | TNFRSF9 active protein

Human 4-1BB receptor, soluble (TNFRSF9)

Cat. Num. AAA691495

• Gene Names: TNFRSF9; ILA; 4-1BB; CD137; CDw137
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analyses
• Synonyms: 4-1BB receptor; soluble (TNFRSF9); Human 4-1BB receptor; Recombinant Human soluble 4-1BB receptor; TNFRSF9 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCD ICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK Q GQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKER DVV CGPSPADLSP GASSVTPPAP AREPGHS
• Sequence Length: 255

• Endotoxin Level: < 0.1 ng per ìg of 4-1BB receptor
• Biological Activity: Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1ug for both 4-1BBL and 4-1BBR.

Related Product Information for TNFRSF9 active protein

4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Product Categories/Family for TNFRSF9 active protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 5730095
• NCBI GeneID: 3604
• NCBI Accession #: NP_001552.2
• NCBI GenBank Nucleotide #: NM_001561.5
• UniProt Accession #: Q07011; AAB34924
• Molecular Weight: 17.7 kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 9
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 9
• NCBI Official Symbol: TNFRSF9
• NCBI Official Synonym Symbols: ILA; 4-1BB; CD137; CDw137
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 9
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF9
• UniProt Synonym Gene Names: CD137; ILA
• UniProt Entry Name: TNR9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit structure: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed on the surface of activated T-cells.

Sequence similarities: Contains 4 TNFR-Cys repeats.