4-1 BB Active Protein | 4-1BB active protein

Human 4-1 BB (Receptor)

Cat. Num. AAA695728

• Gene Names: TNFRSF9; ILA; 4-1BB; CD137; CDw137
• Reactivity: Species Reactivity: Human
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Synonyms: 4-1 BB; Human 4-1 BB (Receptor); Recombinant Human 4-1BB Receptor; 4-1BB active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human
• Purity/Purification: Above 98% as determined by SDS-PAGE Analysis.
• Sequence: MERTRSLQD PCSNCPAGT FCDNNRNQI CSPCPPNSF SSAGGQRTC DICRQCKGV FRTRKECSS TSNAECDCT PGFHCLGAG CSMCEQDCK QGQELTKKG CKNCCFGTF NDQKRGICR PWTNCSLDG KSVLVNGTK ERDVVCGPS PADLSPGAS SVTPPAPAR EPGHS

• Biological Activity: Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1 ug for both 4-1BBL and 4-1BBR.
• Cell Type: T Cells
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for 4-1BB active protein

4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Product Categories/Family for 4-1BB active protein

Adaptive Immunity; Apoptosis; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 728738
• NCBI GeneID: 3604
• UniProt Accession #: Q07011; AAB34924
• Molecular Weight: 27,899 Da
• NCBI Official Full Name: Tumor necrosis factor receptor superfamily member 9
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 9
• NCBI Official Symbol: TNFRSF9
• NCBI Official Synonym Symbols: ILA; 4-1BB; CD137; CDw137
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 9
• UniProt Gene Name: TNFRSF9
• UniProt Synonym Gene Names: CD137; ILA
• UniProt Entry Name: TNR9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function: cytokine binding; receptor activity

Biological Process: negative regulation of cell proliferation; apoptosis