Growth Hormone Active Protein | GH active protein

Human Growth Hormone

Cat. Num. AAA692295

• Gene Names: GH1; GH; GHN; GH-N; GHB5; hGH-N; IGHD1B
• Reactivity: Human
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Synonyms: Growth Hormone; Human Growth Hormone; Somatotropin; GH; GH-N; Growth Hormone 1; Pituitary growth hormone; GH active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFEEAYIPKE QKYSFL QNPQ TSLCFSESIP TPSNREETQQ KSNLELLRIS LLLIQSWLEP V QFLRSVFAN SLVYGASDSN VYDLLKDLEE GIQTLMGRLE DGSPRTG QIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD MDKVETFLRI VQ CRSVEGSC GF
• Sequence Length: 217

• Biological Activity: Determined by its ability to stimulate the proliferation of rat Nb2-11 cells. The expected ED50 is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.

Related Product Information for GH active protein

Growth Hormone (GH), also known as somatotropin, is a pleiotropic cytokine of the hematopoietic growth factor superfamily, which encompasses most cytokines, hematopoietic growth factors, and related receptors, and includes the related growth hormone receptor, prolactin, placental lactogens, proliferins, and somatolactin (SST). GH is primarily recognized for its anabolic role in stimulating the growth and differentiation of muscle, bone, and cartilage. A number of other functions, including immunomodulatory actions, are also attributed to GH, due in part to the pervasive distribution of its receptors, and the indirect effects associated with GH-stimulated production of insulin-like growth factors (IGFs). Occurring predominantly in the somatotropes of the anterior pituitary, whereupon it is stored in secretory granules, production of GH has also been noted in many other tissues, including those of the hematopoietic system. The production and pulsatile release of circulating GH is very tightly regulated by both negative and positive feedback regulations of pituitary and hypothalamic hormones, such as Pituitary-specific Positive Transcription Factor 1 (POU1F1), Growth Hormone Releasing Hormone (GHRH), and somatostatin (SRIF). Deficient production of GH is associated with dwarfism and reduction of lean body mass, while overproduction is associated with acromegaly and gigantism, as well as breast tumor growth. Recombinant Human Growth Hormone is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid residues.

Product Categories/Family for GH active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 134703
• NCBI GeneID: 2688
• UniProt Accession #: P01241; Q14405; Q16631; Q5EB53; Q9HBZ1; Q9UMJ7; Q9UNL5; A6NEF6
• Molecular Weight: 20,201 Da
• NCBI Official Full Name: Somatotropin
• NCBI Official Synonym Full Names: growth hormone 1
• NCBI Official Symbol: GH1
• NCBI Official Synonym Symbols: GH; GHN; GH-N; GHB5; hGH-N; IGHD1B
• NCBI Protein Information: somatotropin
• UniProt Protein Name: Somatotropin
• Protein Family: Growth hormone
• UniProt Gene Name: GH1
• UniProt Synonym Gene Names: GH; GH-N

NCBI Description

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Uniprot Description

GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular region; extracellular space

Molecular Function: growth factor activity; growth hormone receptor binding; prolactin receptor binding; protein binding

Biological Process: glucose transport; JAK-STAT cascade; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of JAK-STAT cascade; positive regulation of MAP kinase activity; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of receptor internalization; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estradiol stimulus

Disease: Isolated Growth Hormone Deficiency, Type Ia; Isolated Growth Hormone Deficiency, Type Ib; Isolated Growth Hormone Deficiency, Type Ii; Kowarski Syndrome