Testing Data
CNTF active protein
Rat CNTF
Reactivity
Species Reactivity: RatCross Reactivity: Frog, Human, Mouse
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
CNTF; Rat CNTF; Recombinant Rat CNTF; CNTF active protein
Host
E Coli
Reactivity
Species Reactivity: Rat
Cross Reactivity: Frog, Human, Mouse
Cross Reactivity: Frog, Human, Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
AFAEQTPLT LHRRDLCSR SIWLARKIR SDLTALMES YVKHQGLNK NINLDSVDG VPVASTDRW SEMTEAERL QENLQAYRT FQGMLTKLL EDQRVHFTP TEGDFHQAI HTLMLQVSA FAYQLEELM VLLEQKIPE NEADGMPAT VGDGGLFEK KLWGLKVLQ ELSQWTVRS IHDLRVISS HQMGISALE SHYGAKDKQ M
Biological Activity
Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml.
Cell Type
Stem Cells, Neurons
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for CNTF active protein
CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant rat CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion.
Product Categories/Family for CNTF active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
22,854 Da
NCBI Official Full Name
Ciliary neurotrophic factor
NCBI Official Synonym Full Names
ciliary neurotrophic factor
NCBI Official Symbol
Cntf
NCBI Protein Information
ciliary neurotrophic factor; ciliary neurotropic factor
UniProt Protein Name
Ciliary neurotrophic factor
Protein Family
UniProt Gene Name
Cntf
UniProt Synonym Gene Names
CNTF
UniProt Entry Name
CNTF_RAT
NCBI Description
a cytokine involved in neuronal degeneration and adipocyte gene expression [RGD, Feb 2006]
Uniprot Description
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Research Articles on CNTF
Similar Products
Product Notes
The CNTF cntf (Catalog #AAA695995) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat CNTF reacts with Species Reactivity: Rat Cross Reactivity: Frog, Human, Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: AFAEQTPLT LHRRDLCSR SIWLARKIR SDLTALMES YVKHQGLNK NINLDSVDG VPVASTDRW SEMTEAERL QENLQAYRT FQGMLTKLL EDQRVHFTP TEGDFHQAI HTLMLQVSA FAYQLEELM VLLEQKIPE NEADGMPAT VGDGGLFEK KLWGLKVLQ ELSQWTVRS IHDLRVISS HQMGISALE SHYGAKDKQ M. It is sometimes possible for the material contained within the vial of "CNTF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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