Fibroblast Growth Factor 16 Active Protein | FGF16 active protein

Recombinant Human Fibroblast Growth Factor 16

Cat. Num. AAA140815

• Gene Names: FGF16; MF4; FGF-16
• Purity: Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
• Synonyms: Fibroblast Growth Factor 16; Recombinant Human Fibroblast Growth Factor 16; FGF16 Human; Fibroblast Growth Factor 16 Human Recombinant; Metacarpal 4-5 Fusion; FGF-16; MF4; FGF16; FGF16 active protein

• Host: E Coli
• Purity/Purification: Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
• Form/Format: FGF-16 0.2 um filtered solution containing 20mM Tris-HCl, 1M NaCl, pH 9.0, 0.2% Tween-20 and 10% Glycerol.; Sterile Filtered colorless clear solution.
• Sequence: AEVGGVFASL DWDLHGFSSS LGNVPLADSP GFLNERLGQI EGKLQRGSPT DFAHLKGILR RRQLYCRTGF HLEIFPNGTV HGTRHDHSRF GILEFISLAV GLISIRGVDS GLYLGMNERG ELYGSKKLTR ECVFREQFEE NWYNTYASTL YKHSDSERQY YVALNKDGSP REGYRTKRHQ KFTHFLPRPV DPSKLPSMSR DLFHYR.
• Sequence Length: 207

• Biological Activity: The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5ng/ml, corresponding to a specific activity of > 2.0 x 106 IU/mg.
• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.

Related Product Information for FGF16 active protein

Introduction: Fibroblast growth factor 16 (FGF16) is a member of the large FGF family, whose members are heparin-binding growth factors with a core 120 amino acid (a.a.) FGF domain which allows for a common tertiary structure. Human FGF16 cDNA is a 207 aa precursor protein with one N-linked glycosylation site. FGF16 though lacking a typical signal peptide, is efficiently produced by mechanisms other than the classical protein secretion pathway. FGF16 is expressed in cardiac cells and is required for proper heart development. FGF16 gene mutation was also observed in individuals with metacarpal 4-5 fusion. FGF16 has an imperative role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Description: FGF16 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 206 amino acids and having a molecular mass of 23.6kDa.The FGF-16 is purified by proprietary chromatographic techniques.

Product Categories/Family for FGF16 active protein

Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4503691
• NCBI GeneID: 8823
• NCBI Accession #: NP_003859.1
• NCBI GenBank Nucleotide #: NM_003868.2
• UniProt Accession #: O43320
• Molecular Weight: 23,759 Da
• NCBI Official Full Name: fibroblast growth factor 16
• NCBI Official Synonym Full Names: fibroblast growth factor 16
• NCBI Official Symbol: FGF16
• NCBI Official Synonym Symbols: MF4; FGF-16
• NCBI Protein Information: fibroblast growth factor 16
• UniProt Protein Name: Fibroblast growth factor 16
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF16
• UniProt Synonym Gene Names: FGF-16
• UniProt Entry Name: FGF16_HUMAN

Uniprot Description

FGF16: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: extracellular region; extracellular space

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; metabolic process; organ morphogenesis; phosphoinositide-mediated signaling; regulation of endothelial cell proliferation; regulation of MAP kinase activity; regulation of phosphoinositide 3-kinase cascade; response to temperature stimulus; signal transduction

Disease: Metacarpal 4-5 Fusion