TARC (CCL17) Active Protein | TARC active protein

Recombinant Human TARC (CCL17)

Cat. Num. AAA4159708

• Gene Names: CCL17; TARC; ABCD-2; SCYA17; A-152E5.3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: TARC (CCL17); Recombinant Human TARC (CCL17); CC chemokine TARC; Small-inducible cytokine A17; C-C motif chemokine 17; chemokine 17; CCL17; ABCD-2; SCYA17; TARC; Recombinant Human Thymus and Activation-Regulated Chemokine (CCL17); TARC active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PB,100 mM NaCl, pH 7.5.
• Sequence Length: 94

• Bioactivity: Determined by its ability to chemoattract human T cells using a concentration range of 2-40 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Related Product Information for TARC active protein

Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in the thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity. The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on CD4 Th2 cells.

NCBI and Uniprot Product Information

• NCBI GI #: 3024711
• NCBI GeneID: 6361
• UniProt Accession #: Q92583
• Molecular Weight: 8.0 kDa
• NCBI Official Full Name: C-C motif chemokine 17
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 17
• NCBI Official Symbol: CCL17
• NCBI Official Synonym Symbols: TARC; ABCD-2; SCYA17; A-152E5.3
• NCBI Protein Information: C-C motif chemokine 17
• UniProt Protein Name: C-C motif chemokine 17
• UniProt Gene Name: CCL17
• UniProt Synonym Gene Names: SCYA17; TARC
• UniProt Entry Name: CCL17_HUMAN

NCBI Description

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL17: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR4 chemokine receptor binding; chemokine activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; multicellular organismal development; immune response; negative regulation of myoblast differentiation; inflammatory response; chemotaxis