Rabbit ZMYND11 Polyclonal Antibody | anti-ZMYND11 antibody

ZMYND11 Polyclonal Antibody

Cat. Num. AAA3011510

• Gene Names: ZMYND11; BS69; BRAM1; MRD30
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ZMYND11; Polyclonal Antibody; ZMYND11 Polyclonal Antibody; Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69; BRAM1; BS69; anti-ZMYND11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ZMYND11 polyclonal antibody detects endogenous levels of ZMYND11 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 548

• Applicable Applications for anti-ZMYND11 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human ZMYND11.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ZMYND11 polyclonal antibody)

Related Product Information for anti-ZMYND11 antibody

The adenovirus E1A gene products are nuclear phosphoproteins with the ability to transactivate other adenovirus genes. BS69 specifically interacts with adenovirus 5 E1A and inhibits transactivation by the 289R E1A protein. BS69 interacts with the co-repressor N-CoR through an essential MYND domain in the carboxy terminus of N-CoR. BS69 also inhibits the transcriptional activity of c-Myb. During oncogenesis, this BS69/Myb regulatory circuit maybe be a target for disruption. Another ubiquitously expressed member of the Myb gene family, b-Myb, also interacts with BS69 and N-CoR to function as a transcriptional repressor. BRAM1, a splice variant of BS69, binds specifically to bone morphogenetic protein type IA receptor (BMPR-IA). BRAM1 localizes to the cytoplasm of mammalian cells, while BS69 localizes to the cell nucleus. Unlike BS69, BRAM1 is unable to repress transcription.

NCBI and Uniprot Product Information

• NCBI GI #: 321117022
• NCBI GeneID: 10771
• NCBI Accession #: NP_001189393.1
• NCBI GenBank Nucleotide #: NP_001189393.1
• UniProt Accession #: Q15326
• Molecular Weight: ~ 71kDa
• NCBI Official Full Name: zinc finger MYND domain-containing protein 11 isoform c
• NCBI Official Synonym Full Names: zinc finger MYND-type containing 11
• NCBI Official Symbol: ZMYND11
• NCBI Official Synonym Symbols: BS69; BRAM1; MRD30
• NCBI Protein Information: zinc finger MYND domain-containing protein 11
• UniProt Protein Name: Zinc finger MYND domain-containing protein 11
• Protein Family: Zinc finger MYND domain-containing protein
• UniProt Gene Name: ZMYND11
• UniProt Synonym Gene Names: BS69
• UniProt Entry Name: ZMY11_HUMAN

NCBI Description

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

ZMYND11: Corepressor of transcription (Probable).

Protein type: Tumor suppressor; Transcription regulation; DNA-binding

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription corepressor activity; methylated histone residue binding

Biological Process: negative regulation of JNK cascade; cell proliferation; transcription, DNA-dependent; viral reproduction; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of I-kappaB kinase/NF-kappaB cascade; cell cycle

Disease: Mental Retardation, Autosomal Dominant 30