FKBP2 active protein

FKBP2, 22-142aa, Human, E Coli (Bioactivity Validated)

Cat. Num. AAA203608

• Gene Names: FKBP2; PPIase; FKBP-13
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: FKBP2; 22-142aa; Human; E Coli (Bioactivity Validated); Peptidyl-prolyl cis-trans isomerase FKBP2; FKBP-13; PPIase; Peptidyl-prolyl cis-trans isomerase FKBP2 13 kDa FKBP; EC 5.2.1.8; FK506 binding protein 2 (13kD); FK506 binding protein 2 13kDa; FKBP 13; FKBP 2; FKBP13; Peptidyl prolyl cis trans isomerase; Proline isomerase; Rapamycin binding protein; Rotamase.; FKBP2 active protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
• Sequence Length: 142

• Applicable Applications for FKBP2 active protein: SDS-PAGE
• Antigen Species: Human
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Biological Activity: Specific activity is > 700 nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmol of suc-AAFP-PNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for FKBP2 active protein

FKBP2 is peptidyl proline isomerase enzyme and a member of the immunophilin protein family. This protein is predominantly expressed in thymus and T cells and plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. FKBP2 is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Recombinant FKBP2 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for FKBP2 active protein

Heat Shock Proteins

References

Walensky LD., et al. (1998) J Cell Biol. 141 (1):143-53. ; Padilla PI., et al. (2003) Proc Natl Acad Sci u S A. 100 (5):2322-7.;

NCBI and Uniprot Product Information

• NCBI GI #: 206725530
• NCBI GeneID: 2286
• NCBI Accession #: NP_001128680
• NCBI GenBank Nucleotide #: NM_001135208.1
• UniProt Accession #: P26885; Q5BJH9; Q9BTS7
• Molecular Weight: 13.4 kDa (122aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP2
• NCBI Official Synonym Full Names: FK506 binding protein 2
• NCBI Official Symbol: FKBP2
• NCBI Official Synonym Symbols: PPIase; FKBP-13
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP2
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP2
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP2
• UniProt Synonym Gene Names: FKBP13; PPIase FKBP2; 13 kDa FKBP; FKBP-13; FKBP-2

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Uniprot Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.