Exodus-2 (CCL21A) Active Protein | CCL21A active protein

Recombinant Mouse Exodus-2 (CCL21A)

Cat. Num. AAA4159921

• Gene Names: Ccl21a; ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Exodus-2 (CCL21A); Recombinant Mouse Exodus-2 (CCL21A); C-C motif chemokine 21a; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4; TCA4; Scya21; Scya21a; Ccl21a; CCL21A active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered PBS solution.
• Sequence Length: 133

• Bioactivity: Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10-100 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Related Product Information for CCL21A active protein

Exodus-2 has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed preferentially in lymph node tissue. Exodus-2 is critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T cell trafficking through nodal tissue.

NCBI and Uniprot Product Information

• NCBI GI #: 302488378
• NCBI GeneID: 18829
• NCBI Accession #: NP_001180596.1
• NCBI GenBank Nucleotide #: NP_001180596.1
• UniProt Accession #: P84444
• Molecular Weight: 12.0 kDa
• NCBI Official Full Name: predicted gene 1987
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 21A (serine)
• NCBI Official Symbol: Ccl21a
• NCBI Official Synonym Symbols: ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545
• NCBI Protein Information: C-C motif chemokine 21a
• UniProt Protein Name: C-C motif chemokine 21a
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl21a
• UniProt Synonym Gene Names: Scya21; Scya21a; TCA4
• UniProt Entry Name: CC21A_MOUSE

Uniprot Description

CCL21a: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T- cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine

Cellular Component: extracellular space; intracellular

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; induction of positive chemotaxis; inflammatory response; lymph node development; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity