Ccl21a recombinant protein

Ccl21a Protein, Mouse, Recombinant

Cat. Num. AAA8123263

• Gene Names: Ccl21a; ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545; MGC107632; Ccl21a
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Ccl21a; Ccl21a Protein; Mouse; Recombinant; Mouse CCL21a Protein; 6CKBAC2 Protein; 6Ckine Protein; ALP Protein; CKb9 Protein; plt Protein; Scya21 Protein; SCYA21a Protein; Scya21b Protein; SLC Protein; Tca4 Protein; chemokine (C-C motif) ligand 21A (serine); Ccl21a recombinant protein

• Host: Baculovirus-Insect Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 40mM Tris, 300mM NaCl, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly133

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Ser 24
• Tag: Native
• Protein Construction: A DNA sequence encoding the mouse CCL21A (NP_035254.1)(Met1-Gly133) was expressed.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 14547891
• NCBI GeneID: 18829
• UniProt Accession #: P84444; O09002; O09006; Q3U1J2; Q91V84
• NCBI Official Full Name: C-C motif chemokine 21b [Mus musculus]
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 21A (serine)
• NCBI Official Symbol: Ccl21a
• NCBI Official Synonym Symbols: ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545; MGC107632; Ccl21a
• UniProt Protein Name: C-C motif chemokine 21a
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl21a
• UniProt Synonym Gene Names: Scya21; Scya21a; TCA4
• UniProt Entry Name: CC21A_MOUSE

Uniprot Description

CCL21a: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T- cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine

Cellular Component: extracellular space; intracellular

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; induction of positive chemotaxis; inflammatory response; lymph node development; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity