Eotaxin (CCL11) Active Protein | CCL11 active protein

Recombinant Mouse Eotaxin (CCL11)

Cat. Num. AAA4159920

• Gene Names: Ccl11; Scya11; eotaxin
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Eotaxin (CCL11); Recombinant Mouse Eotaxin (CCL11); C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; SCYA11; CCL11 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS
• Sequence Length: 97

• Bioactivity: Activity was determined by the ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-20 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Related Product Information for CCL11 active protein

Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils.

NCBI and Uniprot Product Information

• NCBI GI #: 6755418
• NCBI GeneID: 20292
• NCBI Accession #: NP_035460.1
• NCBI GenBank Nucleotide #: NP_035460.1
• UniProt Accession #: P48298
• Molecular Weight: 8.0 kDa
• NCBI Official Full Name: eotaxin
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 11
• NCBI Official Symbol: Ccl11
• NCBI Official Synonym Symbols: Scya11; eotaxin
• NCBI Protein Information: eotaxin
• UniProt Protein Name: Eotaxin
• Protein Family: Eotaxin
• UniProt Gene Name: Ccl11
• UniProt Synonym Gene Names: Scya11
• UniProt Entry Name: CCL11_MOUSE

Uniprot Description

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: chemokine activity; cytokine activity

Biological Process: regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; mast cell chemotaxis; eosinophil chemotaxis; actin filament organization; immune response; cytoskeleton organization and biogenesis; positive regulation of endothelial cell proliferation; chemotaxis; inflammatory response; positive regulation of cell migration