Eotaxin protein (Ccl11) Active Protein | Ccl11 active protein

Recombinant Mouse Eotaxin protein (Ccl11) (Active)

Cat. Num. AAA969247

• Gene Names: Ccl11; Scya11; eotaxin
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Eotaxin protein (Ccl11); Recombinant Mouse Eotaxin protein (Ccl11) (Active); C-C motif chemokine 11; Small-inducible cytokine A11; Ccl11 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Positions: 24-97aa
• Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP
• Sequence Length: 97

• Species: Mus musculus (Mouse)
• Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/ml.
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Protein Note: Protein will be provided with aseptic processing and endotoxin removal.
• Preparation and Storage: Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

SDS-PAGE

Related Product Information for Ccl11 active protein

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

Product Categories/Family for Ccl11 active protein

Biological Active Protein; Immunology; Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 6755418
• NCBI GeneID: 20292
• NCBI Accession #: NP_035460.1
• NCBI GenBank Nucleotide #: NM_011330.3
• UniProt Accession #: P48298
• Molecular Weight: 8.4 kDa
• NCBI Official Full Name: eotaxin
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 11
• NCBI Official Symbol: Ccl11
• NCBI Official Synonym Symbols: Scya11; eotaxin
• NCBI Protein Information: eotaxin
• UniProt Protein Name: Eotaxin
• Protein Family: Eotaxin
• UniProt Gene Name: Ccl11
• UniProt Synonym Gene Names: Scya11

Uniprot Description

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 C|11 49.84 cM

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; CCR3 chemokine receptor binding; chemokine activity; protein dimerization activity; receptor agonist activity

Biological Process: actin filament organization; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; regulation of cell shape