Eotaxin (CCL11) Active Protein | CCL11 active protein

Recombinant Human Eotaxin (CCL11)

Cat. Num. AAA4159647

• Gene Names: CCL11; SCYA11
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Eotaxin (CCL11); Recombinant Human Eotaxin (CCL11); SCYA11; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; CCL11 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from as 0.2 um filtered solution in PBS (pH 7.5)
• Sequence Length: 97

• Bioactivity: Activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for CCL11 active protein

Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils.

NCBI and Uniprot Product Information

• NCBI GI #: 4506827
• NCBI GeneID: 6356
• NCBI Accession #: NP_002977.1
• NCBI GenBank Nucleotide #: NP_002977.1
• UniProt Accession #: P51671
• Molecular Weight: 8.5 kDa
• NCBI Official Full Name: eotaxin
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 11
• NCBI Official Symbol: CCL11
• NCBI Official Synonym Symbols: SCYA11
• NCBI Protein Information: eotaxin
• UniProt Protein Name: Eotaxin
• Protein Family: Eotaxin
• UniProt Gene Name: CCL11
• UniProt Synonym Gene Names: SCYA11
• UniProt Entry Name: CCL11_HUMAN

NCBI Description

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity

Biological Process: chronic inflammatory response; mast cell chemotaxis; response to virus; actin filament organization; cytoskeleton organization and biogenesis; signal transduction; chemotaxis; protein amino acid phosphorylation; cellular calcium ion homeostasis; regulation of cell shape; positive regulation of angiogenesis; response to radiation; positive regulation of actin filament polymerization; eosinophil chemotaxis; positive regulation of endothelial cell proliferation; immune response; inflammatory response; cell adhesion; positive regulation of cell migration

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To