Eotaxin-2 (CCL24) Active Protein | CCL24 active protein

Recombinant Human Eotaxin-2 (CCL24)

Cat. Num. AAA4159648

• Gene Names: CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Eotaxin-2 (CCL24); Recombinant Human Eotaxin-2 (CCL24); CCL24; C-C motif chemokine 24; CK-beta-6; Eosinophil chemotactic protein 2; Myeloid progenitor inhibitory factor 2; MPIF-2; Small-inducible cytokine A24; CCL24 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from 0.2 um filtered concentrated (1.0mg/mL) solution in 100m M NaCl, 10 mM PB, pH 7.0.
• Sequence Length: 119

• Bioactivity: Activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Related Product Information for CCL24 active protein

Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils.

NCBI and Uniprot Product Information

• NCBI GI #: 6920081
• NCBI GeneID: 6369
• UniProt Accession #: O00175
• Molecular Weight: 9.0 kDa
• NCBI Official Full Name: C-C motif chemokine 24
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 24
• NCBI Official Symbol: CCL24
• NCBI Official Synonym Symbols: Ckb-6; MPIF2; MPIF-2; SCYA24
• NCBI Protein Information: C-C motif chemokine 24
• UniProt Protein Name: C-C motif chemokine 24
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL24
• UniProt Synonym Gene Names: MPIF2; SCYA24; MPIF-2
• UniProt Entry Name: CCL24_HUMAN

NCBI Description

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL24: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cytoskeleton organization and biogenesis; chemotaxis; signal transduction; regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; cell-cell signaling; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; inflammatory response; positive regulation of inflammatory response; positive regulation of cell migration