Betacellulin Active Protein | BTC active protein

Betacellulin, Recombinant, Human

Cat. Num. AAA650210

• Purity: Highly Purified; 98% by SDS-PAGE and HPLC analyses. Endoxoxin: 0.1EU/ug
• Synonyms: Betacellulin; Recombinant; Human; BTC active protein

• Host: E Coli
• Purity/Purification: Highly Purified; 98% by SDS-PAGE and HPLC analyses. Endoxoxin: 0.1EU/ug
• Form/Format: Supplied as lyophilized powder. Reconstitute in sterile ddH2O, to 0.1-1mg/ml, which can then be further diluted to other aqueous solutions

• Specific Activity: 2x10e7units/mg.
• Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is 0.05ng/ml.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.Country of Origin:; USA

Related Product Information for BTC active protein

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0kD transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0kD monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Product Categories/Family for BTC active protein

Growth Factors; Cytokines; Growth Factors-Other

NCBI and Uniprot Product Information

• NCBI GI #: 265786
• NCBI GeneID: 685
• UniProt Accession #: P35070; Q96F48; Q86UF5
• Molecular Weight: 9.0kD
• NCBI Official Full Name: betacellulin
• NCBI Official Synonym Full Names: betacellulin
• NCBI Official Symbol: BTC
• NCBI Protein Information: probetacellulin; OTTHUMP00000160600; OTTHUMP00000219057
• UniProt Protein Name: Probetacellulin
• Protein Family: Probetacellulin
• UniProt Gene Name: BTC
• UniProt Entry Name: BTC_HUMAN

NCBI Description

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq]

Uniprot Description

Function: Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.

Subunit structure: Monomer.

Subcellular location: Betacellulin: Secreted › extracellular space. Probetacellulin: Cell membrane; Single-pass type I membrane protein.

Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. Ref.3

Sequence similarities: Contains 1 EGF-like domain.