Dysbindin Recombinant Protein | DTNBP1 recombinant protein

Dysbindin, 1-270aa, Human, His tag, E Coli

Cat. Num. AAA203176

• Gene Names: DTNBP1; SDY; DBND; HPS7; My031; BLOC1S8
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: Dysbindin; 1-270aa; Human; His tag; E Coli; Dystrobrevin-binding protein 1 isoform C; DTNBP1; DBND; HPS7; SDY; Dystrobrevin-binding protein 1 isoform C Dystrobrevin binding protein 1; Hermansky Pudlak syndrome 7 protein.; DTNBP1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: In 20 mM Tris-HCl Buffer (pH 8.0) containing 100mM NaCl, 0.5mM DTT, 20% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMLS AHWEKKKTSL VELQEQLQQL PALIADLESM TANLTHLEAS FEEVENNLLH LEDLCGQCEL ERCKHMQSQQ LENYKKNKRK ELETFKAELD AEHAQKVLEM EHTQQMKLKE RQKFFEEAFQ QDMEQYLSTG YLQIAERREP IGSMSSMEVN VDMLEQMDLM DISDQEALDV FLNSGGEENT VLSPALGPES STCQNEITLQ VPNPSELRAK PPSSSSTCTD SATRDISEGG ESPVVQSDEE EVQVDTALAT SHTDREATPD GGEDSDS
• Sequence Length: 270

• Applicable Applications for DTNBP1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for DTNBP1 recombinant protein

Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes. Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for DTNBP1 recombinant protein

Neuroscience

References

Li W., et al. (2003). Nat Genet. 35 (1):84-9; Chen XW., et al. (2008). J Cell Biol. 181 (5):791-801;

NCBI and Uniprot Product Information

• NCBI GI #: 34304370
• NCBI GeneID: 84062
• NCBI Accession #: NP_898862
• NCBI GenBank Nucleotide #: NM_183041.1
• Molecular Weight: 34.6 kDa (307aa), confirmed by MALDI-TOF.
• NCBI Official Synonym Full Names: dystrobrevin binding protein 1
• NCBI Official Symbol: DTNBP1
• NCBI Official Synonym Symbols: SDY; DBND; HPS7; My031; BLOC1S8
• NCBI Protein Information: dysbindin
• UniProt Protein Name: Dysbindin
• Protein Family: Dysbindin
• UniProt Gene Name: DTNBP1
• UniProt Synonym Gene Names: BLOC1S8; BLOC-1 subunit 8; HPS7 protein

NCBI Description

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.