DnaJ homolog subfamily C member 10 (DNAJC10) Recombinant Protein | DNAJC10 recombinant protein
Recombinant Human DnaJ homolog subfamily C member 10 (DNAJC10)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Uniprot Description
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Research Articles on DNAJC10
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Product Notes
The DNAJC10 dnajc10 (Catalog #AAA1430413) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 33-793, Full length protein. The amino acid sequence is listed below: DQDFYSLLGV SKTASSREIR QAFKKLALKL HPDKNPNNPN AHGDFLKINR AYEVLKDEDL RKKYDKYGEK GLEDNQGGQY ESWNYYRYDF GIYDDDPEII TLERREFDAA VNSGELWFVN FYSPGCSHCH DLAPTWRDFA KEVDGLLRIG AVNCGDDRML CRMKGVNSYP SLFIFRSGMA PVKYHGDRSK ESLVSFAMQH VRSTVTELWT GNFVNSIQTA FAAGIGWLIT FCSKGGDCLT SQTRLRLSGM LDGLVNVGWM DCATQDNLCK SLDITTSTTA YFPPGATLNN KEKNSILFLN SLDAKEIYLE VIHNLPDFEL LSANTLEDRL AHHRWLLFFH FGKNENSNDP ELKKLKTLLK NDHIQVGRFD CSSAPDICSN LYVFQPSLAV FKGQGTKEYE IHHGKKILYD ILAFAKESVN SHVTTLGPQN FPANDKEPWL VDFFAPWCPP CRALLPELRR ASNLLYGQLK FGTLDCTVHE GLCNMYNIQA YPTTVVFNQS NIHEYEGHHS AEQILEFIED LMNPSVVSLT PTTFNELVTQ RKHNEVWMVD FYSPWCHPCQ VLMPEWKRMA RTLTGLINVG SIDCQQYHSF CAQENVQRYP EIRFFPPKSN KAYHYHSYNG WNRDAYSLRI WGLGFLPQVS TDLTPQTFSE KVLQGKNHWV IDFYAPWCGP CQNFAPEFEL LARMIKGKVK AGKVDCQAYA QTCQKAGIRA YPTVKFYFYE RAKRNFQEEQ INTRDAKAIA ALISEKLETL RNQGKRNKDE L. It is sometimes possible for the material contained within the vial of "DnaJ homolog subfamily C member 10 (DNAJC10), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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