Deoxyguanosine kinase, mitochondrial (Dguok) Recombinant Protein | Dguok recombinant protein
Recombinant Mouse Deoxyguanosine kinase, mitochondrial (Dguok)
Gene Names
Dguok; dGK; dGK1; dGK2; dGK3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Deoxyguanosine kinase; mitochondrial (Dguok); Recombinant Mouse Deoxyguanosine kinase; Dguok recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
40-277, full length protein
Sequence
RLCIEGNIAVGKSTFVKLLMKTHPEWQVATEPIAEWQNIQAAGAQKDGTSKRLGNLLEMMYQEPARWSYTFQTLSFMSRLKVQLEPIPGRLLQAEKSVRVFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLQEFANRLLLHGFIYLQASPQVCMERLYQRDREEEKGIELAYLQQLHSQHEDWFINKTTKLHFEALQHVPVLVLDVTEDFSENAARQEELMGQVNTFMRNL
Sequence Length
238
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Dguok recombinant protein
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. This protein is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,808 Da
NCBI Official Full Name
deoxyguanosine kinase, mitochondrial isoform 1
NCBI Official Synonym Full Names
deoxyguanosine kinase
NCBI Official Symbol
Dguok
NCBI Official Synonym Symbols
dGK; dGK1; dGK2; dGK3
NCBI Protein Information
deoxyguanosine kinase, mitochondrial
UniProt Protein Name
Deoxyguanosine kinase, mitochondrial
UniProt Gene Name
Dguok
UniProt Synonym Gene Names
Dgk; dGK
Uniprot Description
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
Research Articles on Dguok
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Product Notes
The Dguok dguok (Catalog #AAA1346919) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 40-277, full length protein. The amino acid sequence is listed below: RLCIEGNIAV GKSTFVKLLM KTHPEWQVAT EPIAEWQNIQ AAGAQKDGTS KRLGNLLEMM YQEPARWSYT FQTLSFMSRL KVQLEPIPGR LLQAEKSVRV FERSVYSDRY IFAKNLFENG SLSDIEWHIY QDWHSFLLQE FANRLLLHGF IYLQASPQVC MERLYQRDRE EEKGIELAYL QQLHSQHEDW FINKTTKLHF EALQHVPVLV LDVTEDFSEN AARQEELMGQ VNTFMRNL. It is sometimes possible for the material contained within the vial of "Deoxyguanosine kinase, mitochondrial (Dguok), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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