Mouse cylindromatosis (turban tumor syndrome) ELISA Kit | CYLD elisa kit
Mouse Ubiquitin carboxyl-terminal hydrolase CYLD, CYLD ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Uniprot Description
CYLD: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with SQSTM1 and MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. Inhibited by phosphorylation at serine residues. Belongs to the peptidase C67 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Protease; Ubiquitin conjugating system; EC 3.4.19.12; Ubiquitin-specific protease
Cellular Component: nucleoplasm; centrosome; microtubule; extrinsic to internal side of plasma membrane; cell projection; cytoskeleton; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; spindle; midbody; cytosol
Molecular Function: peptidase activity; protein binding; hydrolase activity; zinc ion binding; metal ion binding; ubiquitin-specific protease activity; protein kinase binding; cysteine-type peptidase activity
Biological Process: ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein deubiquitination; inhibition of NF-kappaB transcription factor; regulation of mitotic cell cycle; negative regulation of NF-kappaB import into nucleus; proteolysis; negative regulation of T cell differentiation
Research Articles on CYLD
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Product Notes
The Mouse CYLD cyld (Catalog #AAA9326599) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326599 ELISA Kit recognizes Mouse CYLD. It is sometimes possible for the material contained within the vial of "cylindromatosis (turban tumor syndrome), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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