Cardiotrophin-1 (CT-1) Recombinant Protein | CT-1 recombinant protein

Recombinant Human Cardiotrophin-1 (CT-1)

Cat. Num. AAA4159846

• Gene Names: CTF1; CT1; CT-1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Cardiotrophin-1 (CT-1); Recombinant Human Cardiotrophin-1 (CT-1); Recombinant Human Cardiotrophin-1; CTF1; CT1; CT-1; CT-1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS
• Sequence Length: 201

• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile 20mM Tris, pH 8.0 at 100ug/mL (containing at least 0.1% human or bovine serum albumin). Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1-1.0% BSA.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for CT-1 recombinant protein

Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine.

NCBI and Uniprot Product Information

• NCBI GI #: 4503121
• NCBI GeneID: 1489
• NCBI Accession #: NP_001321.1
• NCBI GenBank Nucleotide #: NP_001321.1
• UniProt Accession #: Q16619
• Molecular Weight: 21.0 kDa
• NCBI Official Full Name: cardiotrophin-1 isoform 1
• NCBI Official Synonym Full Names: cardiotrophin 1
• NCBI Official Symbol: CTF1
• NCBI Official Synonym Symbols: CT1; CT-1
• NCBI Protein Information: cardiotrophin-1
• UniProt Protein Name: Cardiotrophin-1
• Protein Family: Cardiotrophin
• UniProt Gene Name: CTF1
• UniProt Synonym Gene Names: CT-1
• UniProt Entry Name: CTF1_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

CTF1: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: leukemia inhibitory factor receptor binding; cytokine activity

Biological Process: nervous system development; cell proliferation; muscle development; cell-cell signaling; leukemia inhibitory factor signaling pathway; positive regulation of cell proliferation; neuron development