Cytotoxic and regulatory T-cell molecule Recombinant Protein | CRTAM recombinant protein

Cytotoxic and regulatory T-cell molecule, 18-287aa, Human, His tag, Baculovirus

Cat. Num. AAA206353

• Gene Names: CRTAM; CD355
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: Cytotoxic and regulatory T-cell molecule; 18-287aa; Human; His tag; Baculovirus; CRTAM; CD355; CRTAM recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 1mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: SLTNHTETIT VEEGQTLTLK CVTSLRKNSS LQWLTPSGFT IFLNEYPALK NSKYQLLHHS ANQLSITVPN VTLQDEGVYK CLHYSDSVST KEVKVIVLAT PFKPILEASV IRKQNGEEHV VLMCSTMRSK PPPQITWLLG NSMEVSGGTL HEFETDGKKC NTTSTLIIHT YGKNSTVDCI IRHRGLQGRK LVAPFRFEDL VTDEETASDA LERNSLSSQD PQQPTSTVSV TEDSSTSEID KEEKEQTTQD PDLTTEANPQ YLGLARKKSG LEHHHHHH
• Sequence Length: 393

• Applicable Applications for CRTAM recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CRTAM recombinant protein

CRTAM, also known as cytotoxic and regulatory T-cell molecule, is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. This protein interacts with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombinant human CRTAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for CRTAM recombinant protein

Immunology

References

Kennedy J., et al. (2000) J. Leukoc. Biol. 67:725-734.; Boles K.S., et al. (2005) Blood 106:779-786.

NCBI and Uniprot Product Information

• NCBI GI #: 51593098
• NCBI GeneID: 56253
• NCBI Accession #: NP_062550
• NCBI GenBank Nucleotide #: NM_019604.3
• UniProt Accession #: O95727; Q59EI1; Q6IRX2
• Molecular Weight: 31.0kDa (278aa) 40-57KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: cytotoxic and regulatory T-cell molecule Isoform 1
• NCBI Official Synonym Full Names: cytotoxic and regulatory T cell molecule
• NCBI Official Symbol: CRTAM
• NCBI Official Synonym Symbols: CD355
• NCBI Protein Information: cytotoxic and regulatory T-cell molecule
• UniProt Protein Name: Cytotoxic and regulatory T-cell molecule
• Protein Family: Cytotoxic and regulatory T-cell molecule
• UniProt Gene Name: CRTAM

NCBI Description

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

Uniprot Description

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.