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Thymic Stromal Lymphopoietin Receptor/TSP R Recombinant Protein | TSP R recombinant protein

Recombinant Mouse Thymic Stromal Lymphopoietin Receptor/TSP R Protein (C-Fc)

Gene Names
Crlf2; CRLM2; Ly114; Tpte2; Tslpr
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Thymic Stromal Lymphopoietin Receptor/TSP R; Recombinant Mouse Thymic Stromal Lymphopoietin Receptor/TSP R Protein (C-Fc); CRL2; CRLF2; CRL2 cytokine receptor; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR; TSP R recombinant protein
Ordering
For Research Use Only!
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Sequence Positions
Ala20-Leu233
Sequence Length
370
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-Fc
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for TSP R recombinant protein
The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common gamma receptor-like chain (TSLPR-gamma) and a common interleukin 7 (IL-7) Ralpha chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Ralpha chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 49.8 kDa
Actual Protein Molecular Mass: 62-88 kDa
NCBI Official Full Name
cytokine receptor-like factor 2 isoform 1
NCBI Official Synonym Full Names
cytokine receptor-like factor 2
NCBI Official Symbol
Crlf2
NCBI Official Synonym Symbols
CRLM2; Ly114; Tpte2; Tslpr
NCBI Protein Information
cytokine receptor-like factor 2
UniProt Protein Name
Cytokine receptor-like factor 2
UniProt Gene Name
Crlf2
UniProt Synonym Gene Names
Crlm2; Tpte2; Tslpr; CRLM-2; TSLP receptor

Uniprot Description

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.

Research Articles on TSP R

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Product Notes

The TSP R crlf2 (Catalog #AAA2553626) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Ala20-Leu233. It is sometimes possible for the material contained within the vial of "Thymic Stromal Lymphopoietin Receptor/TSP R, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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