Chloride Intracellular Channel Protein 4 Recombinant Protein | CLIC4 recombinant protein

Recombinant Human Chloride Intracellular Channel Protein 4

Cat. Num. AAA2556637

• Gene Names: CLIC4; H1; huH1; p64H1; CLIC4L; MTCLIC
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Chloride Intracellular Channel Protein 4; Recombinant Human Chloride Intracellular Channel Protein 4; Intracellular Chloride Ion Channel Protein p64H1; CLIC4; CLIC4 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0.
• Sequence Length: 253

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Met1-Lys253
• Fusion Tag: N-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt.; Please minimize freeze-thaw cycles.

SDS-Page

Related Product Information for CLIC4 recombinant protein

Protein Construction: Recombinant Human Chloride Intracellular Channel Protein 4 is produced by our E Coli expression system and the target gene encoding Met1-Lys253 is expressed with a 6His tag at the N-terminus.

Background: Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). CLIC4 acts as a monomer which is able to form selective ion channels in target proteins, thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions. CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.

NCBI and Uniprot Product Information

• NCBI GI #: 7330335
• NCBI GeneID: 25932
• NCBI Accession #: NP_039234.1
• NCBI GenBank Nucleotide #: NM_013943.3
• UniProt Accession #: Q9Y696; Q9UFW9; Q9UQJ6
• Molecular Weight: Molecular Mass: 30.9kDa; Actual Protein Molecular Mass: 32kDa
• NCBI Official Full Name: chloride intracellular channel protein 4
• NCBI Official Synonym Full Names: chloride intracellular channel 4
• NCBI Official Symbol: CLIC4
• NCBI Official Synonym Symbols: H1; huH1; p64H1; CLIC4L; MTCLIC
• NCBI Protein Information: chloride intracellular channel protein 4
• UniProt Protein Name: Chloride intracellular channel protein 4
• Protein Family: Chloride intracellular channel protein
• UniProt Gene Name: CLIC4

NCBI Description

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Uniprot Description

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).