AChR alpha3 Blocking Peptide | CHRNA3 blocking peptide

AChR alpha3 Blocking Peptide

Cat. Num. AAA9627531

• Gene Names: CHRNA3; LNCR2; PAOD2; NACHRA3
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: AChR alpha3; AChR alpha3 Blocking Peptide; ACHA3_HUMAN; AChR; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; LNCR2; MGC104879; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit; PAOD2; CHRNA3 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for CHRNA3 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHRNA3 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 19923122
• NCBI GeneID: 1136
• NCBI Accession #: NP_000734.2
• NCBI GenBank Nucleotide #: NM_000743.4
• UniProt Accession #: P32297; Q15823; Q4KMN8; Q86U77; Q96RH3; Q99553; Q9BQ93; Q9BRR4
• Molecular Weight: 55,637 Da
• NCBI Official Full Name: neuronal acetylcholine receptor subunit alpha-3 isoform 1
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic alpha 3 subunit
• NCBI Official Symbol: CHRNA3
• NCBI Official Synonym Symbols: LNCR2; PAOD2; NACHRA3
• NCBI Protein Information: neuronal acetylcholine receptor subunit alpha-3
• UniProt Protein Name: Neuronal acetylcholine receptor subunit alpha-3
• Protein Family: Neuronal acetylcholine receptor
• UniProt Gene Name: CHRNA3
• UniProt Synonym Gene Names: NACHRA3
• UniProt Entry Name: ACHA3_HUMAN

Uniprot Description

nAChRA3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; dendrite; postsynaptic density; plasma membrane; integral to membrane; cell junction

Molecular Function: acetylcholine receptor activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: regulation of smooth muscle contraction; nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); regulation of dendrite morphogenesis; regulation of acetylcholine secretion; behavioral response to nicotine; locomotory behavior; signal transduction; synaptic transmission, cholinergic; synaptic transmission; regulation of membrane potential; ion transport; synaptic transmission involved in micturition; regulation of excitatory postsynaptic membrane potential

Disease: Smoking As A Quantitative Trait Locus 3