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Alkaline phosphatase, tissue-nonspecific isozyme (Alpl) Recombinant Protein | Alpl recombinant protein
Recombinant Rat Alkaline phosphatase, tissue-nonspecific isozyme (Alpl)
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SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
catalyzes the conversion of an orthophosphoric monoester to an alcohol phosphate [RGD, Feb 2006]
Uniprot Description
ALPL: This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.1; Membrane protein, GPI anchor; Phosphatase (non-protein); Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - folate biosynthesis
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; membrane; plasma membrane
Molecular Function: pyrophosphatase activity; alkaline phosphatase activity; metal ion binding
Biological Process: response to antibiotic; osteoblast differentiation; response to vitamin D; dephosphorylation; response to glucocorticoid stimulus; reproductive developmental process; response to lipopolysaccharide; endochondral ossification
Research Articles on Alpl
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Product Notes
The Alpl alpl (Catalog #AAA718986) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-501aa; Full Length of Mature Protein. The amino acid sequence is listed below: FVPEKEKDPS YWRQQAQETL KNALKLQKLN TNVAKNIIMF LGDGMGVSTV TAARILKGQL HHNTGEETRL EMDKFPFVAL SKTYNTNAQV PDSAGTATAY LCGVKANEGT VGVSAATERT RCNTTQGNEV TSILRWAKDA GKSVGIVTTT RVNHATPSAA YAHSADRDWY SDNEMPPEAL SQGCKDIAYQ LMHNIKDIDV IMGGGRKYMY PKNRTDVEYE LDEKARGTRL DGLDLISIWK SFKPRHKHSH YVWNRTELLA LDPSRVDYLL GLFEPGDMQY ELNRNNLTDP SLSEMVEVAL RILTKNPKGF FLLVEGGRID HGHHEGKAKQ ALHEAVEMDE AIGKAGTMTS QKDTLTVVTA DHSHVFTFGG YTPRGNSIFG LAPMVSDTDK KPFTAILYGN GPGYKVVDGE RENVSMVDYA HNNYQAQSAV PLRHETHGGE DVAVFAKGPM AHLLHGVHEQ NYIPHVMAYA SCIGANLDHC AWAS. It is sometimes possible for the material contained within the vial of "Alkaline phosphatase, tissue-nonspecific isozyme (Alpl), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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