Immunoglobulin Lambda Protein | Igl protein

Eukaryotic Immunoglobulin Lambda (Igl)

Cat. Num. AAA2122485

• Applications: SDS-Page, Western Blot
• Purity: >97%
• Synonyms: Immunoglobulin Lambda; Eukaryotic Immunoglobulin Lambda (Igl); IGL@ protein; Igl protein

• Host: CHO Cell
• Purity/Purification: >97%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Met1~Ser235
• Sequence Length: 498

• Applicable Applications for Igl protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Eukaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for Igl protein

Hematology

NCBI and Uniprot Product Information

• NCBI GI #: 4502837
• NCBI GeneID: 1143
• NCBI Accession #: NP_000741.1
• NCBI GenBank Nucleotide #: NP_000741.1
• UniProt Accession #: P30926
• Molecular Weight: Predicted Molecular Mass: 26.4kDa; Accurate Molecular Mass: 28kDa
• NCBI Official Full Name: neuronal acetylcholine receptor subunit beta-4 isoform 1
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic beta 4 subunit
• NCBI Official Symbol: CHRNB4
• NCBI Protein Information: neuronal acetylcholine receptor subunit beta-4
• UniProt Protein Name: Neuronal acetylcholine receptor subunit beta-4
• Protein Family: Immunoglobulin lambda variable
• UniProt Gene Name: CHRNB4
• UniProt Entry Name: ACHB4_HUMAN

NCBI Description

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

Uniprot Description

nAChRB4: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 4/CHRNB4 sub-subfamily.

Protein type: Receptor, misc.; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; integral to plasma membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: regulation of smooth muscle contraction; synaptic transmission; regulation of action potential; smooth muscle contraction; regulation of neurotransmitter secretion; behavioral response to nicotine; locomotory behavior; ion transport; synaptic transmission involved in micturition; signal transduction; cation transport; synaptic transmission, cholinergic