CEA Blocking Peptide | CEACAM5 blocking peptide

CEA Antibody (Center) Blocking Peptide

• Gene Names: CEACAM5; CEA; CD66e
• Synonyms: CEA; CEA Antibody (Center) Blocking Peptide; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; Meconium antigen 100; CD66e; CEACAM5; CEACAM5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human CEA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 702

• Cellular Location: Cell membrane; Lipid-anchor, GPI-anchor
• Tissue Location: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CEACAM5 blocking peptide

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

NCBI and Uniprot Product Information

• NCBI GI #: 317373456
• NCBI GeneID: 1048
• UniProt Accession #: P06731; H9KVA7
• Molecular Weight: 76,724 Da
• NCBI Official Full Name: Carcinoembryonic antigen-related cell adhesion molecule 5
• NCBI Official Synonym Full Names: carcinoembryonic antigen related cell adhesion molecule 5
• NCBI Official Symbol: CEACAM5
• NCBI Official Synonym Symbols: CEA; CD66e
• NCBI Protein Information: carcinoembryonic antigen-related cell adhesion molecule 5
• UniProt Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 5
• Protein Family: CEACAM1-like protein
• UniProt Gene Name: CEACAM5
• UniProt Synonym Gene Names: CEA; CEA
• UniProt Entry Name: CEAM5_HUMAN

NCBI Description

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Description

CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.

Protein type: Membrane protein, GPI anchor; Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function: identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis