WDR77 cdna clone
WDR77
Translation Sequence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV RDATWSPLNH SLLTTVGWDH QVVHHVVPTE PLPAPGPASV TE
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Description
WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; spliceosomal snRNP biogenesis; positive regulation of cell proliferation; gene expression
Research Articles on WDR77
Similar Products
Product Notes
The WDR77 wdr77 (Catalog #AAA200781) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGCGGAAGG AAACCCCACC CCCCCTAGTG CCCCCGGCGG CCCGGGAGTG GAATCTTCCC CCAAATGCGC CCGCCTGCAT GGAACGGCAG TTGGAGGCTG CGCGGTACCG GTCCGATGGG GCGCTTCTCC TCGGGGCCTC CAGCCTGAGT GGGCGCTGCT GGGCCGGCTC CCTCTGGCTT TTTAAGGACC CCTGTGCCGC CCCCAACGAA GGCTTCTGCT CCGCCGGAGT CCAAACGGAG GCTGGAGTGG CTGACCTCAC TTGGGTTGGG GAGAGAGGTA TTCTAGTGGC CTCCGATTCA GGTGCTGTTG AATTGTGGGA ACTAGATGAG AATGAGACAC TTATTGTCAG CAAGTTCTGC AAGTATGAGC ATGATGACAT TGTGTCTACA GTCAGTGTCT TGAGCTCTGG CACACAAGCT GTCAGTGGTA GCAAAGACAT CTGCATCAAG GTTTGGGACC TTGCTCAGCA GGTGGTACTG AGTTCATACC GAGCTCATGC TGCTCAGGTC ACTTGTGTTG CTGCCTCTCC TCACAAGGAC TCTGTGTTTC TTTCATGCAG CGAGGACAAT AGAATTTTAC TCTGGGATAC CCGCTGTCCC AAGCCAGCAT CACAGATTGG CTGCAGTGCG CCTGGCTACC TTCCTACCTC GCTGGCTTGG CATCCTCAGC AAAGTGAAGT CTTTGTCTTT GGTGATGAGA ATGGGACAGT CTCCCTTGTG GACACCAAGA GTACAAGCTG TGTCCTGAGC TCAGCTGTAC ACTCCCAGTG TGTCACTGGG CTGGTGTTCT CCCCACACAG TGTTCCCTTC CTGGCCTCTC TCAGTGAAGA CTGCTCACTT GCTGTGCTGG ACTCAAGCCT TTCTGAGTTG TTTAGAAGCC AAGCCCACAG AGACTTTGTG AGAGATGCGA CTTGGTCCCC GCTCAATCAC TCCCTGCTTA CCACAGTGGG CTGGGACCAT CAGGTCGTCC ACCACGTTGT GCCCACAGAA CCTCTCCCAG CCCCTGGACC TGCAAGTGTT ACTGAGTAG< br> Tra nslation Sequence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV RDATWSPLNH SLLTTVGWDH QVVHHVVPTE PLPAPGPASV TE. It is sometimes possible for the material contained within the vial of "WDR77, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
