VX-765 (Belnacasan), Inhibitor

VX-765 (Belnacasan)

Cat. Num. AAA386389

• Purity: >98%
• Synonyms: VX-765 (Belnacasan); VX765; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 19.65 mL (1 mg); 98.23 mL (5 mg); 196.46mL (10 mg); 0.5 mM: 3.93 mL (1 mg); 19.65 mL (5 mg); 39.29 mL (10 mg); 1 mM: 1.96 mL (1 mg); 9.82 mL (5 mg); 19.65 mL (10 mg); 5 mM: 0.39 mL (1 mg); 1.96 mL (5 mg); 3.93 mL (10 mg) (varies by lot)

• CAS Number: 273404-37-8
• Formula: C24H33ClN4O6
• SMILES: CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
• Actions: Inhibitor
• Solubility (DMSO): 100 mg/mL heating (196.46 mM)
• Solubility (Ethanol): 100 mg/mL heating (196.46 mM)
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for VX-765 (Belnacasan), inhibitor

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

References

Joseph Flores, .et al. Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer-s disease mouse model, Nat Commun, 2018, 9: 3916 PMID: 30254377
Mohamed F. Ali, .et al. Canonical Stimulation of the NLRP3 Inflammasome by Fungal Antigens Links Innate and Adaptive B-Lymphocyte Responses by Modulating IL-1β and IgM Production, Front Immunol, 2017, 8: 1504 PMID: 29170665
García-Fernández A, .et al. Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles, J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553
Jiujiu Yu, .et al. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy, Proc Natl Acad Sci U S A., 2014, 111(43): 15514-15519 PMID: 25313054