UBR7 cdna clone
UBR7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]
Uniprot Description
UBR7: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 14q32.12
Research Articles on UBR7
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Product Notes
The UBR7 ubr7 (Catalog #AAA1271798) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgatccagt gcgtagtctg tgaagactgg ttccatggaa ggcatcttgg tgccattccc cctgagagtg gggattttca ggagatggta tgccaggcct gcatgaaacg ttgttctttt ttgtgggctt atgctgcaca attggcagta accaaaatat ccactgagga tgatggattg gtgcggaaca ttgatggaat aggtgatcag gaagttatca aacctgaaaa tggagagcat caagatagta ccctcaaaga ggatgttcca gaacagggaa aggatgatgt ccgggaggtt aaagtagagc agaacagtga accatgtgcc ggctctagtt ctgaatctga tctccagaca gtgtttaaga atgaaagcct caacgcagaa tcaaaatctg gctgcaaact tcaggagctt aaagctaagc agcttataaa gaaagacact gccacctatt ggcccctgaa ctggcgtagc aagttgtgta cctgccaaga ctgtatgaaa atgtatggag atctagatgt cttattcctg acagatgaat acgacacagt tctggcttat gaaaacaaag ggaagattgc ccaggccact gacaggagcg atcccctaat ggataccctt agcagcatga atagagtcca gcaagtggaa ctcatttgtg aatacaatga tttgaagact gaacttaaag actatctcaa gagatttgct gatgaaggca cggttgttaa gagagaggac attcagcagt tctttgaaga gtttcagtca aaaaagagaa gaagagtgga tgggatgcag tattactgca gctag. It is sometimes possible for the material contained within the vial of "UBR7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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