Rabbit ABCG4 Polyclonal Antibody | anti-ABCG4 antibody

Anti-ABCG4 antibody

Cat. Num. AAA176160

• Gene Names: ABCG4; WHITE2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: ABCG4; Polyclonal Antibody; Anti-ABCG4 antibody; ATP-binding cassette sub-family G member 4; ATP-binding cassette; sub-family G(WHITE); member 4; ABCG 4 antibody; ATP binding cassette subfamily G member 4 antibody; member 4 antibody; Putative ABC transporter antibody; WHITE 2 antibody; WHITE2 antibody; anti-ABCG4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 646

• Applicable Applications for anti-ABCG4 antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human ABCG4 (327-341aa AVQNGLCAMAEKKSS), different from the related mouse and rat sequences by one amino acid.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-ABCG4 antibody, MBS176160, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue Lysate )

Related Product Information for anti-ABCG4 antibody

Description: Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family G member 4(ABCG4) detection. Tested with WB in Human, Mouse, Rat.
Background: ABCG4(ATP-Binding Cassette, Subfamily G, Member 4), is a protein that in humans is encoded by the ABCG4 gene. The protein encoded by this gene is included in the superfamily of ATP-binding cassette(ABC) transporters. This protein is a member of the White subfamily and is expressed predominantly in liver tissue. By genomic sequence analysis, Engel et al.(2001) mapped the ABCG4 gene to chromosome 11q23.3. Engel et al.(2001) demonstrated 5-fold induction of ABCG4 following treatment of normal monocyte-derived macrophages with the LXR and RXR agonists 9-cis retinoic acid and 22R hydroxycholesterol. Removal of cholesterol from macrophages by cyclodextrin decreased ABCG4 message levels.

NCBI and Uniprot Product Information

• NCBI GI #: 17432915
• NCBI GeneID: 64137
• UniProt Accession #: Q9H172; Q8WWH0; Q8WWH1; Q8WWH2; A8K1B5
• Molecular Weight: 60,903 Da
• NCBI Official Full Name: ATP-binding cassette sub-family G member 4
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family G (WHITE), member 4
• NCBI Official Symbol: ABCG4
• NCBI Official Synonym Symbols: WHITE2
• NCBI Protein Information: ATP-binding cassette sub-family G member 4; putative ABC transporter; ATP-binding cassette, subfamily G, member 4
• UniProt Protein Name: ATP-binding cassette sub-family G member 4
• Protein Family: ABC transporter G family
• UniProt Gene Name: ABCG4
• UniProt Synonym Gene Names: WHITE2
• UniProt Entry Name: ABCG4_HUMAN

NCBI Description

The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding

Biological Process: metabolic process; cholesterol efflux; transmembrane transport