SNW1 cdna clone
SNW1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Description
Skip: Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing. Belongs to the SNW family.
Protein type: Nuclear receptor co-regulator; Spliceosome; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: nuclear matrix; nucleoplasm; nucleus; spliceosome; transcription elongation factor complex b
Molecular Function: Notch binding; nuclear hormone receptor binding; protein binding; retinoic acid receptor binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; vitamin D receptor binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; nuclear mRNA splicing, via spliceosome; positive regulation of histone H3-K4 methylation; positive regulation of neurogenesis; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of retinoic acid receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter
Research Articles on SNW1
Similar Products
Product Notes
The SNW1 snw1 (Catalog #AAA1271247) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGCTCA CCAGCTTTTT ACCTGCACCT ACTCAGCTAT CTCAGGACCA GCTTGAGGCT GAAGAAAAGG CAAGATCCCA GAGATCACGG CAGACCTCAC TGGTCTCCTC CCGAAGAGAA CCTCCCCCGT ACGGATACCG GAAAGGCTGG ATACCTCGGT TATTAGAGGA TTTTGGAGAT GGAGGTGCTT TTCCAGAGAT CCATGTGGCC CAGTATCCAC TGGATATGGG ACGAAAGAAA AAAATGTCGA ATGCGCTGGC CATTCAGGTG GATTCTGAAG GAAAAATTAA ATATGATGCA ATTGCTCGAC AAGGACAGTC AAAAGACAAG GTCATTTATA GCAAATACAC TGACCTGGTT CCAAAGGAGG TTATGAATGC AGATGATCCA GACCTGCAAA GGCCCGATGA AGAAGCTATT AAAGAGATAA CAGAAAAGAC AAGAGTAGCC TTAGAAAAAT CTGTATCACA GAAGGTCGCC GCAGCCATGC CAGTTCGAGC AGCTGACAAA TTGGCTCCTG CTCAGTATAT CCGATACACA CCATCTCAGC AAGGAGTGGC ATTCAACTCT GGAGCTAAAC AGAGGGTTAT TCGGATGGTA GAAATGCAGA AAGATCCAAT GGAGCCTCCA AGGTTCAAGA TTAATAAGAA AATTCCCCGG GGACCACCTT CTCCTCCTGC GCCTGTCATG CATTCTCCTA GCCGAAAGAT GACTGTAAAG GAACAACAAG AGTGGAAGAT TCCTCCTTGT ATTTCTAACT GGAAAAATGC AAAGGGTTAT ACAATTCCAT TAGACAAACG TCTGGCTGCT GATGGAAGAG GACTACAGAC AGTACACATA AATGAAAATT TCGCCAAATT GGCAGAAGCC CTCTACATTG CTGATCGGAA GGCTCGTGAA GCTGTGGAAA TGCGTGCCCA AGTAGAGAGA AAAATGGCTC AGAAAGAAAA GGAAAAACAT GAAGAGAAAC TTAGAGAAAT GGCCCAGAAA GCCAGGGAAA GAAGAGCTGG GATCAAAACT CATGTGGAAA AAGAGGATGG GGAGGCACGT GAGAGGGATG AAATCCGGCA TGACAGGCGA AAAGAGAGAC AGCATGACCG GAATCTTTCC AGGGCAGCTC CTGATAAGAG GTCGAAACTT CAGAGAAATG AAAATCGGGA TATCAGTGAA GTTATTGCTC TCGGTGTTCC TAATCCTCGG ACTTCCAATG AAGTTCAGTA TGACCAAAGG CTCTTCAACC AATCCAAGGG TATGGACAGT GGATTTGCAG GTGGAGAAGA TGAAATTTAT AATGTTTATG ATCAAGCCTG GAGAGGTGGT AAAGATATGG CCCAGAGTAT TTATAGGCCC AGTAAAAATC TGGACAAGGA CATGTATGGT GATGACCTAG AAGCCAGAAT AAAGACCAAC AGATTTGTTC CCGACAAGGA GTTTTCTGGT TCAGACCGTA GACAGAGAGG CCGAGAAGGA CCAGTTCAGT TTGAGGAAGA TCCTTTTGGT TTGGACAAGT TTTTGGAAGA AGCCAAACAG CATGGTGGCT CTAAAAGACC CTCAGATAGC AGCCGCCCCA AGGAACACGA GCATGAAGGC AAGAAGAGGA GGAAGGAATA G. It is sometimes possible for the material contained within the vial of "SNW1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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