SEMA5A cdna clone

SEMA5A cDNA Clone

Gene Names

SEMA5A; semF; SEMAF

Synonyms

SEMA5A; SEMA5A cDNA Clone; SEMA5A cdna clone

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Cat. Num. AAA1266773 For Research Use Only!

Sequence

ATGAAGGGAACCTGTGTTATAGCATGGCTGTTCTCAAGCCTGGGGCTGTGGAGACTCGCCCACCCAGAGGCCCAGGGTACGACTCAGTGCCAGAGAACCGAGCATCCAGTCATCTCCTATAAAGAAATTGGCCCCTGGTTACGGGAGTTCAGAGCGAAGAATGCTGTGGATTTCTCGCAGTTAACATTTGACCCAGGACAGAAAGAACTTGTTGTAGGAGCAAGAAACTACCTCTTCAGGTTACAGCTTGAGGATCTGTCTCTTATCCAGGCTGTGGAATGGGAGTGTGATGAAGCTACCAAAAAGGCCTGTTACAGCAAAGGCAAATCAAAGGAGGAATGTCAGAACTACATCCGGGTGCTTCTGGTGGGTGGCGACCGGTTATTCACCTGTGGGACCAATGCATTCACGCCTGTCTGCACCAACCGCTCGTTGAGCAACCTGACTGAGATCCATGATCAGATCAGTGGCATGGCCCGCTGTCCCTACAGTCCCCAGCACAATTCCACAGCGCTCCTCACAGCTGGTGGGGAGCTCTATGCTGCTACAGCCATGGATTTTCCAGGACGTGATCCTGCCATTTACCGAAGCCTAGGCATTTTACCTCCTCTCCGCACGGCGCAGTACAACTCCAAATGGCTCAATGAGCCAAACTTTGTGTCATCTTATGACATCGGAAATTTTACCTACTTCTTTTTCCGAGAAAATGCAGTAGAGCATGACTGTGGGAAAACAGTGTTCTCCAGAGCTGCCCGGGTGTGCAAGAACGATATTGGTGGGCGCTTCCTGCTGGAAGACACCTGGACCACATTCATGAAGGCTCGCCTGAACTGCTCCCGTCCTGGGGAAGTCCCCTTTTACTACAACGAATTGCAGAGTACTTTCTTCCTGCCTGAGCTGGATTTGATCTATGGCATCTTTACCACCAATGTGAACAGCATTGCGGCCTCAGCTGTGTGCGTCTTCAACCTGAGCGCCATCGCGCAGGCCTTCTCTGGGCCCTTCAAGTACCAAGAAAACTCGCGCTCGGCCTGGCTACCGTATCCCAACCCAAACCCCCACTTCCAGTGTGGCACCGTGGACCAGGGCCTGTACGTGAACCTGACCGAGAGAAATCTGCAGGATGCTCAGAAGTTCATTCTGATGCATGAGGTGGTACAGCCAGTGACCACAGTGCCCTCCTTCATGGAGGACAATAGCCGCTTTTCCCACGTGGCAGTCGACGTGGTGCAGGGCAGAGAAGCGCTCGTCCACATCATCTATTTGGCCACAGATTACGGAACCATTAAGAAAGTGCGGGTACCCCTGAATCAGACCTCAAGCAGCTGTTTGCTGGAAGAGATTGAGCTCTTCCCTGAGAGGCGGAGGGAGCCCATCAGGAGCCTGCAGATCCTGCACAGCCAGAGTGTCCTGTTCGTGGGCCTGCGGGAGCACGTGGTCAAGATCCCCCTGAAGAGGTGCCAGTTCTACCGCACACGCAGCACCTGCATTGGGGCCCAGGACCCTTACTGTGGCTGGGATGTGGTAATGAAGAAATGCACAAGCCTGGAGGAGAGCCTGAGCATGACGCAGTGGGAACAGAGCATCTCTGCGTGTCCGACCAGGAATCTCACCGTGGATGGGCACTTTGGTGTGTGGTCTCCGTGGACGCCTTGCACGCACACAGATGGCAGCGCCGTGGGATCCTGCCTCTGTCGAACCCGCTCCTGCGACAGCCCGGCCCCGCAGTGTGGTGGCTGGCAGTGCGAGGGCCCTGGCATGGAGATCGCCAACTGTTCCAGGAACGGAGGCTGGACTCCCTGGACCTCGTGGTCTCCCTGCAGCACTACCTGTGGGATCGGCTTCCAGGTGCGGCAGCGCTCCTGCAGCAACCCCACTCCCAGGCACGGGGGCCGGGTGTGCGTGGGACAGAACCGCGAGGAAAGATACTGCAATGAACATTTGCTATGTCCCCCACACATGTTCTGGACAGGCTGGGGTCCTTGGGAACGGTGCACAGCCCAATGCGGGGGTGGCATTCAAGCTCGCCGCAGGATCTGTGAGAATGGGCCTGACTGTGCAGGCTGCAATGTGGAGTACCAGTCTTGCAACACCAACCCGTGTCCTGAGCTGAAGAAGACCACGCCCTGGACACCCTGGACACCTGTCAACATCTCTGACAACGGCGGCCACTATGAGCAACGATTCCGATACACATGCAAAGCCCGCCTGGCTGATCCGAATTTGCTGGAAGTGGGAAGACAGAGAATCGAAATGCGGTACTGTTCTAGCGACGGCACCAGTGGCTGCTCCACAGATGGGCTTTCTGGGGATTTCCTGCGTGCTGGGAGATACTCTGCCCACACGGTCAACGGGGCTTGGTCAGCCTGGACGTCGTGGTCACAGTGCAGCCGTGACTGCAGCAGGGGCATTCGGAACCGGAAGCGTGTTTGCAACAACCCCGAACCCAAGTATGGGGGAATGCCTTGCCTTGGCCCATCTCTGGAATACCAGGAATGCAACATTTTGCCCTGCCCAGTGGATGGCGTGTGGTCTTGCTGGTCCCCCTGGACAAAATGTTCAGCAACATGCGGCGGTGGACACTATATGAGGACCCGCTCTTGCTCCAATCCAGCCCCGGCCTATGGAGGGGACATCTGCCTGGGGCTGCACACAGAAGAGGCACTCTGCAACACGCAGCCCTGCCCAGAGAGCTGGTCGGAGTGGTCGGACTGGTCTGAGTGTGAAGCCTCTGGCGTCCAAGTCCGCGCCCGCCAGTGCATCCTCCTGTTCCCCATGGGCAGCCAGTGCTCCGGGAACACCACGGAGAGCCGGCCGTGTGTGTTTGACTCTAATTTCATCCCAGAAGTATCTGTGGCAAGATCCAGTAGCGTAGAAGAGAAAAGGTGTGGAGAGTTCAACATGTTCCACATGATCGCCGTGGGGCTGAGCAGCTCCATCCTCGGCTGCCTCCTCACCCTGCTCGTCTATACTTACTGCCAGCGGTACCAGCAGCAATCCCACGATGCGACTGTCATCCACCCCGTCTCACCTGCCCCCCTTAATACCAGCATAACCAACCACATCAACAAACTGGACAAGTACGACTCGGTGGAGGCCATCAAGGCATTTAACAAAAACAACTTGATCCTAGAGGAAAGAAACAAATACTTCAACCCACATCTCACTGGGAAGACCTATTCTAATGCCTACTTTACAGATCTCAATAATTATGATGAGTACTAA

Sequence Length

3225

Vector

pUC

Clone Sequence Report

Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #

92110208

NCBI GeneID

9037

Molecular Weight

120,615 Da

NCBI Official Full Name

Homo sapiens sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A, mRNA

NCBI Official Synonym Full Names

semaphorin 5A

NCBI Official Symbol

SEMA5A

NCBI Official Synonym Symbols

semF; SEMAF

NCBI Protein Information

semaphorin-5A

UniProt Protein Name

Semaphorin-5A

Protein Family

Semaphorin

UniProt Gene Name

SEMA5A

UniProt Synonym Gene Names

SEMAF; Sema F

UniProt Entry Name

SEM5A_HUMAN

NCBI Description

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

Uniprot Description

SEMA5A: a single-pass type I membrane protein that may act as positive axonal guidance cues.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: chemorepellent activity; heparan sulfate proteoglycan binding; semaphorin receptor binding; syndecan binding

Biological Process: axonal fasciculation; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell adhesion; cell-cell signaling; diencephalon development; negative regulation of axon extension involved in axon guidance; negative regulation of cell adhesion; nervous system development; neural crest cell migration; positive chemotaxis; positive regulation of actin filament depolymerization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling cascade

Research Articles on SEMA5A

1. The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development.

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Product Notes

The SEMA5A sema5a (Catalog #AAA1266773) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAGGGAA CCTGTGTTAT AGCATGGCTG TTCTCAAGCC TGGGGCTGTG GAGACTCGCC CACCCAGAGG CCCAGGGTAC GACTCAGTGC CAGAGAACCG AGCATCCAGT CATCTCCTAT AAAGAAATTG GCCCCTGGTT ACGGGAGTTC AGAGCGAAGA ATGCTGTGGA TTTCTCGCAG TTAACATTTG ACCCAGGACA GAAAGAACTT GTTGTAGGAG CAAGAAACTA CCTCTTCAGG TTACAGCTTG AGGATCTGTC TCTTATCCAG GCTGTGGAAT GGGAGTGTGA TGAAGCTACC AAAAAGGCCT GTTACAGCAA AGGCAAATCA AAGGAGGAAT GTCAGAACTA CATCCGGGTG CTTCTGGTGG GTGGCGACCG GTTATTCACC TGTGGGACCA ATGCATTCAC GCCTGTCTGC ACCAACCGCT CGTTGAGCAA CCTGACTGAG ATCCATGATC AGATCAGTGG CATGGCCCGC TGTCCCTACA GTCCCCAGCA CAATTCCACA GCGCTCCTCA CAGCTGGTGG GGAGCTCTAT GCTGCTACAG CCATGGATTT TCCAGGACGT GATCCTGCCA TTTACCGAAG CCTAGGCATT TTACCTCCTC TCCGCACGGC GCAGTACAAC TCCAAATGGC TCAATGAGCC AAACTTTGTG TCATCTTATG ACATCGGAAA TTTTACCTAC TTCTTTTTCC GAGAAAATGC AGTAGAGCAT GACTGTGGGA AAACAGTGTT CTCCAGAGCT GCCCGGGTGT GCAAGAACGA TATTGGTGGG CGCTTCCTGC TGGAAGACAC CTGGACCACA TTCATGAAGG CTCGCCTGAA CTGCTCCCGT CCTGGGGAAG TCCCCTTTTA CTACAACGAA TTGCAGAGTA CTTTCTTCCT GCCTGAGCTG GATTTGATCT ATGGCATCTT TACCACCAAT GTGAACAGCA TTGCGGCCTC AGCTGTGTGC GTCTTCAACC TGAGCGCCAT CGCGCAGGCC TTCTCTGGGC CCTTCAAGTA CCAAGAAAAC TCGCGCTCGG CCTGGCTACC GTATCCCAAC CCAAACCCCC ACTTCCAGTG TGGCACCGTG GACCAGGGCC TGTACGTGAA CCTGACCGAG AGAAATCTGC AGGATGCTCA GAAGTTCATT CTGATGCATG AGGTGGTACA GCCAGTGACC ACAGTGCCCT CCTTCATGGA GGACAATAGC CGCTTTTCCC ACGTGGCAGT CGACGTGGTG CAGGGCAGAG AAGCGCTCGT CCACATCATC TATTTGGCCA CAGATTACGG AACCATTAAG AAAGTGCGGG TACCCCTGAA TCAGACCTCA AGCAGCTGTT TGCTGGAAGA GATTGAGCTC TTCCCTGAGA GGCGGAGGGA GCCCATCAGG AGCCTGCAGA TCCTGCACAG CCAGAGTGTC CTGTTCGTGG GCCTGCGGGA GCACGTGGTC AAGATCCCCC TGAAGAGGTG CCAGTTCTAC CGCACACGCA GCACCTGCAT TGGGGCCCAG GACCCTTACT GTGGCTGGGA TGTGGTAATG AAGAAATGCA CAAGCCTGGA GGAGAGCCTG AGCATGACGC AGTGGGAACA GAGCATCTCT GCGTGTCCGA CCAGGAATCT CACCGTGGAT GGGCACTTTG GTGTGTGGTC TCCGTGGACG CCTTGCACGC ACACAGATGG CAGCGCCGTG GGATCCTGCC TCTGTCGAAC CCGCTCCTGC GACAGCCCGG CCCCGCAGTG TGGTGGCTGG CAGTGCGAGG GCCCTGGCAT GGAGATCGCC AACTGTTCCA GGAACGGAGG CTGGACTCCC TGGACCTCGT GGTCTCCCTG CAGCACTACC TGTGGGATCG GCTTCCAGGT GCGGCAGCGC TCCTGCAGCA ACCCCACTCC CAGGCACGGG GGCCGGGTGT GCGTGGGACA GAACCGCGAG GAAAGATACT GCAATGAACA TTTGCTATGT CCCCCACACA TGTTCTGGAC AGGCTGGGGT CCTTGGGAAC GGTGCACAGC CCAATGCGGG GGTGGCATTC AAGCTCGCCG CAGGATCTGT GAGAATGGGC CTGACTGTGC AGGCTGCAAT GTGGAGTACC AGTCTTGCAA CACCAACCCG TGTCCTGAGC TGAAGAAGAC CACGCCCTGG ACACCCTGGA CACCTGTCAA CATCTCTGAC AACGGCGGCC ACTATGAGCA ACGATTCCGA TACACATGCA AAGCCCGCCT GGCTGATCCG AATTTGCTGG AAGTGGGAAG ACAGAGAATC GAAATGCGGT ACTGTTCTAG CGACGGCACC AGTGGCTGCT CCACAGATGG GCTTTCTGGG GATTTCCTGC GTGCTGGGAG ATACTCTGCC CACACGGTCA ACGGGGCTTG GTCAGCCTGG ACGTCGTGGT CACAGTGCAG CCGTGACTGC AGCAGGGGCA TTCGGAACCG GAAGCGTGTT TGCAACAACC CCGAACCCAA GTATGGGGGA ATGCCTTGCC TTGGCCCATC TCTGGAATAC CAGGAATGCA ACATTTTGCC CTGCCCAGTG GATGGCGTGT GGTCTTGCTG GTCCCCCTGG ACAAAATGTT CAGCAACATG CGGCGGTGGA CACTATATGA GGACCCGCTC TTGCTCCAAT CCAGCCCCGG CCTATGGAGG GGACATCTGC CTGGGGCTGC ACACAGAAGA GGCACTCTGC AACACGCAGC CCTGCCCAGA GAGCTGGTCG GAGTGGTCGG ACTGGTCTGA GTGTGAAGCC TCTGGCGTCC AAGTCCGCGC CCGCCAGTGC ATCCTCCTGT TCCCCATGGG CAGCCAGTGC TCCGGGAACA CCACGGAGAG CCGGCCGTGT GTGTTTGACT CTAATTTCAT CCCAGAAGTA TCTGTGGCAA GATCCAGTAG CGTAGAAGAG AAAAGGTGTG GAGAGTTCAA CATGTTCCAC ATGATCGCCG TGGGGCTGAG CAGCTCCATC CTCGGCTGCC TCCTCACCCT GCTCGTCTAT ACTTACTGCC AGCGGTACCA GCAGCAATCC CACGATGCGA CTGTCATCCA CCCCGTCTCA CCTGCCCCCC TTAATACCAG CATAACCAAC CACATCAACA AACTGGACAA GTACGACTCG GTGGAGGCCA TCAAGGCATT TAACAAAAAC AACTTGATCC TAGAGGAAAG AAACAAATAC TTCAACCCAC ATCTCACTGG GAAGACCTAT TCTAATGCCT ACTTTACAGA TCTCAATAAT TATGATGAGT ACTAA. It is sometimes possible for the material contained within the vial of "SEMA5A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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SEMA5A cdna clone