SCO2 cdna clone
SCO2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
Uniprot Description
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: mitochondrial matrix; mitochondrion; myofibril; nucleoplasm
Molecular Function: protein binding
Biological Process: eye development
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO2
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Product Notes
The SCO2 sco2 (Catalog #AAA1275334) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTGCTGC TGACTCGGAG CCCCACAGCT TGGCACAGGC TCTCTCAGCT CAAGCCTCGG GTCCTCCCTG GGACCCTGGG AGGCCAGGCC CTGCATCTGA GGTCCTGGCT TTTGTCAAGG CAGGGCCCTG CAGAGACAGG TGGGCAGGGC CAGCCCCAGG GCCCTGGGCT TCGAACCCGG CTGCTGATCA CAGGCCTGTT CGGGGCTGGA CTCGGTGGGG CCTGGCTGGC CCTGAGGGCT GAGAAGGAGA GGCTGCAGCA GCAAAAGCGA ACAGAAGCCC TGCGCCAGGC AGCTGTGGGC CAGGGCGACT TCCACCTGCT GGATCACAGA GGCCGGGCTC GCTGCAAGGC TGACTTCCGG GGCCAGTGGG TGCTGATGTA CTTTGGCTTC ACTCACTGCC CTGACATCTG CCCAGACGAG CTGGAGAAGC TGGTGCAGGT GGTGCGGCAG CTGGAAGCAG AGCCTGGTTT GCCTCCAGTG CAGCCTGTCT TCATCACTGT GGACCCCGAG CGGGACGACG TTGAAGCCAT GGCCCGCTAC GTCCAGGACT TCCACCCAAG ACTGTTGGGT CTGACCGGCT CCACCAAACA GGTTGCCCAG GCTAGTCACA GTTACCGCGT GTACTACAAT GCAGGCCCCA AGGATGAGGA CCAGGACTAC ATCGTGGACC ACTCCATTGC CATCTACCTG CTCAACCCTG ACGGCCTCTT CACGGATTAC TACGGCCGGA GCAGATCGGC TGAGCAGATC TCAGACAGTG TGCGGCGGCA CATGGCGGCT TTCCGCAGTG TCCTGTCTTG A. It is sometimes possible for the material contained within the vial of "SCO2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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