RNF111 cdna clone

RNF111 cDNA Clone

Gene Names

RNF111; ARK

Synonyms

RNF111; RNF111 cDNA Clone; RNF111 cdna clone

Ordering
Cat. Num. AAA1271108 For Research Use Only!

Sequence

atgtctcaatggactcctgaatataaggagctctacaccttaaaagtggatatgaagagtgagattccttctgatgcaccaaagacacaggagagtctgaaagggatccttttgcatccagagcccattggggcagccaaaagttttcctgcaggagttgagatgattaatagtaaagtggggaatgaattctctcacctgtgtgatgattctcaaaagcaagagaaggaaatgaatggtaaccagcaagaacaagaaaaaagtctcgttgtgaggaaaaaacgcaaaagccagcaggctggcccttcgtatgtgcagaattgtgttaaagaaaaccagggaatattaggactgaggcaacacctagggacaccaagtgatgaagataatgattcctcttttagtgattgtctttcttctccttcatctagtctgcattttggggattctgatactgtgacttcagatgaggataaagaagtctctgtaagacattcccagaccattttgaatgctaaaagtagaagccatagtgcacggtctcataagtggcctcggactgagacagaatctgtatcgggattgttaatgaaaagaccctgtttacatggcagttcgttacggagacttccatgcagaaagagatttgtaaaaaataattcctcacagaggacacagaaacaaaaagagaggatattaatgcagaggaagaaacgagaagtgttagctcgaagaaaatatgccttgctacctagttctagtagttccagtgagaatgacctcagcagtgaatcctcttctagctcatcaactgaaggagaagaagatttgtttgtttctgccagtgaaaaccaccaaaacaatccagctgttccctcaggaagtattgatgaagatgttgtggtgatagaagcttcctccactccccaggttactgccaatgaagaaattaatgttacctcaactgacagtgaagtggagattgtaacagttggagaaagctatcggtctcgttcaacccttggacactccagatctcattggagccagggttccagttctcatgcaagtcggccacaggagccacggaaccgcagtaggatttctactgttatacagcccttgaggcagaatgcagcagaagttgtggaccttaccgttgatgaagatgaacctactgtagtaccaaccacttctgcaagaatggaatcacaagctactagcgcttccattaacaattcaaatccatctacctctgagcaggcctctgatactgcttcagctgtcaccagtagccaaccttccacagtgtcagagacttcagctactcttacaagcaatagtaccactggcacttctataggagatgactcaaggagaactacatctagtgctgtaacggaaactggccctcctgcaatgccaaggttaccttcctgctgtccccagcactcaccatgtggagggtcgtcacagaaccaccatgcattaggacatcctcatacaagttgctttcagcagcatggtcaccattttcaacatcatcaccaccaccaccatactccccacccagctgtcccagtttctccttcctttagtgatcctgcttgccctgtggaaagacctccacaagtacaagcaccttgtggagcaaatagtagttctggtaccagctatcatgaacaggcattgccagtggacctgagcaacagtggtatcagaagtcatggaagtggcagttttcatggagcatctgcatttgacccctgctgccctgtttcttcctcccgagctgcaatctttggccatcaggccgctgctgctgccccaagtcaacctttatcatcaatagatggctatggatcaagcatggttgcgcagccccagccccagccccctccacagccctctctctcatcatgtcgacattacatgccacccccttatgcctctttgacaaggccacttcatcatcaagcttctgcctgcccgcattctcatggaaacccccctcctcagactcagcctccgcctcaagtggattatgttattcctcatcctgtacatgctttccattctcaaatatcttctcatgcaacatctcatcctgtggcacccccaccaccaactcacttagccagtacagctgcaccaatccctcagcatcttcctcctacacaccagccaatttcgcaccatattccagccacagcacctccagcacagagactgcatcctcatgaagtgatgcagaggatggaagttcaaaggaggaggatgatgcagcatccaacgcgggcacatgaacgccccccaccccatccacataggatgcacccaaactatggtcatgggcatcatattcatgtgcctcagactatgtcctcacatcctcgacaggctccagagaggtctgcctgggaactgggaattgaagctggagtgactgcagctacttatacacctggtgcattgcatcctcacttggcccattatcacgcacctcctcgacttcatcacttacaattaggagctcttcctttaatggttcctgatatggcaggctatcctcacatccgttacatttcatcaggattggatggaacatcattcagaggtcctttcaggggcaattttgaggaactgattcatttggaagaaagattaggcaatgtcaatcgtggagcatcccaggggacaattgaaagatgtacatatccacataaatacaaaaagaggaaactgcactgcaaacaagatggggaagaagggactgaggaagacacagaggaaaaatgtactatctgtttgtctattttagaggaaggtgaagatgtgagacgtcttccatgtatgcaccttttccaccaagtgtgtgttgaccaatggttgattaccaataagaagtgccccatatgcagagtggacattgaggcccagctgccaagtgaaagttga

Sequence Length

2958

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

38173841

NCBI GeneID

54778

Molecular Weight

108,906 Da

NCBI Official Full Name

Homo sapiens ring finger protein 111, mRNA

NCBI Official Synonym Full Names

ring finger protein 111

NCBI Official Symbol

RNF111

NCBI Official Synonym Symbols

ARK

NCBI Protein Information

E3 ubiquitin-protein ligase Arkadia

UniProt Protein Name

E3 ubiquitin-protein ligase Arkadia

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

RNF111

UniProt Entry Name

RN111_HUMAN

NCBI Description

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Uniprot Description

RNF111: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; SUMO polymer binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process

Research Articles on RNF111

1. Results suggest that -459CpG methylation in Sp1-binding site of RNF111 promoter transcriptionally decreases RNF111 expression, which inhibits TGF-beta/Smad signaling associated invasion in NSCLC cells.

Similar Products

Product Notes

The RNF111 rnf111 (Catalog #AAA1271108) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctcaat ggactcctga atataaggag ctctacacct taaaagtgga tatgaagagt gagattcctt ctgatgcacc aaagacacag gagagtctga aagggatcct tttgcatcca gagcccattg gggcagccaa aagttttcct gcaggagttg agatgattaa tagtaaagtg gggaatgaat tctctcacct gtgtgatgat tctcaaaagc aagagaagga aatgaatggt aaccagcaag aacaagaaaa aagtctcgtt gtgaggaaaa aacgcaaaag ccagcaggct ggcccttcgt atgtgcagaa ttgtgttaaa gaaaaccagg gaatattagg actgaggcaa cacctaggga caccaagtga tgaagataat gattcctctt ttagtgattg tctttcttct ccttcatcta gtctgcattt tggggattct gatactgtga cttcagatga ggataaagaa gtctctgtaa gacattccca gaccattttg aatgctaaaa gtagaagcca tagtgcacgg tctcataagt ggcctcggac tgagacagaa tctgtatcgg gattgttaat gaaaagaccc tgtttacatg gcagttcgtt acggagactt ccatgcagaa agagatttgt aaaaaataat tcctcacaga ggacacagaa acaaaaagag aggatattaa tgcagaggaa gaaacgagaa gtgttagctc gaagaaaata tgccttgcta cctagttcta gtagttccag tgagaatgac ctcagcagtg aatcctcttc tagctcatca actgaaggag aagaagattt gtttgtttct gccagtgaaa accaccaaaa caatccagct gttccctcag gaagtattga tgaagatgtt gtggtgatag aagcttcctc cactccccag gttactgcca atgaagaaat taatgttacc tcaactgaca gtgaagtgga gattgtaaca gttggagaaa gctatcggtc tcgttcaacc cttggacact ccagatctca ttggagccag ggttccagtt ctcatgcaag tcggccacag gagccacgga accgcagtag gatttctact gttatacagc ccttgaggca gaatgcagca gaagttgtgg accttaccgt tgatgaagat gaacctactg tagtaccaac cacttctgca agaatggaat cacaagctac tagcgcttcc attaacaatt caaatccatc tacctctgag caggcctctg atactgcttc agctgtcacc agtagccaac cttccacagt gtcagagact tcagctactc ttacaagcaa tagtaccact ggcacttcta taggagatga ctcaaggaga actacatcta gtgctgtaac ggaaactggc cctcctgcaa tgccaaggtt accttcctgc tgtccccagc actcaccatg tggagggtcg tcacagaacc accatgcatt aggacatcct catacaagtt gctttcagca gcatggtcac cattttcaac atcatcacca ccaccaccat actccccacc cagctgtccc agtttctcct tcctttagtg atcctgcttg ccctgtggaa agacctccac aagtacaagc accttgtgga gcaaatagta gttctggtac cagctatcat gaacaggcat tgccagtgga cctgagcaac agtggtatca gaagtcatgg aagtggcagt tttcatggag catctgcatt tgacccctgc tgccctgttt cttcctcccg agctgcaatc tttggccatc aggccgctgc tgctgcccca agtcaacctt tatcatcaat agatggctat ggatcaagca tggttgcgca gccccagccc cagccccctc cacagccctc tctctcatca tgtcgacatt acatgccacc cccttatgcc tctttgacaa ggccacttca tcatcaagct tctgcctgcc cgcattctca tggaaacccc cctcctcaga ctcagcctcc gcctcaagtg gattatgtta ttcctcatcc tgtacatgct ttccattctc aaatatcttc tcatgcaaca tctcatcctg tggcaccccc accaccaact cacttagcca gtacagctgc accaatccct cagcatcttc ctcctacaca ccagccaatt tcgcaccata ttccagccac agcacctcca gcacagagac tgcatcctca tgaagtgatg cagaggatgg aagttcaaag gaggaggatg atgcagcatc caacgcgggc acatgaacgc cccccacccc atccacatag gatgcaccca aactatggtc atgggcatca tattcatgtg cctcagacta tgtcctcaca tcctcgacag gctccagaga ggtctgcctg ggaactggga attgaagctg gagtgactgc agctacttat acacctggtg cattgcatcc tcacttggcc cattatcacg cacctcctcg acttcatcac ttacaattag gagctcttcc tttaatggtt cctgatatgg caggctatcc tcacatccgt tacatttcat caggattgga tggaacatca ttcagaggtc ctttcagggg caattttgag gaactgattc atttggaaga aagattaggc aatgtcaatc gtggagcatc ccaggggaca attgaaagat gtacatatcc acataaatac aaaaagagga aactgcactg caaacaagat ggggaagaag ggactgagga agacacagag gaaaaatgta ctatctgttt gtctatttta gaggaaggtg aagatgtgag acgtcttcca tgtatgcacc ttttccacca agtgtgtgtt gaccaatggt tgattaccaa taagaagtgc cccatatgca gagtggacat tgaggcccag ctgccaagtg aaagttga. It is sometimes possible for the material contained within the vial of "RNF111, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...

RNF111 cdna clone