PIAS2 cdna clone
PIAS2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
Uniprot Description
PIAS2: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Belongs to the PIAS family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nucleoplasm; nucleus; PML body
Molecular Function: protein binding; SUMO ligase activity; transcription factor binding
Biological Process: protein sumoylation
Research Articles on PIAS2
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Product Notes
The PIAS2 pias2 (Catalog #AAA1278724) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggatt tcgaagagtt gaggaatatg gtttctagtt ttagggtttc tgaactacaa gtattactag gctttgctgg acggaataaa agtggacgca agcatgacct cctgatgagg gcgctgcatt tattgaagag cggctgcagc cctgcggttc agattaaaat ccgagaattg tatagacgcc gatatccacg aactcttgaa ggactttctg atttatccac aatcaaatca tcggttttca gtttggatgg tggctcatca cctgtagaac ctgacttggc cgtggctgga atccactcgt tgccttccac ttcagttaca cctcactcac catcctctcc tgttggttct gtgctgcttc aagatactaa gcccacattt gagatgcagc agccatctcc cccaattcct cctgtccatc ctgatgtgca gttaaaaaat ctgccctttt atgatgtcct tgatgttctc atcaagccca cgagtttagt tcaaagcagt attcagcgat ttcaagagaa gttttttatt tttgctttga cacctcaaca agttagagag atatgcatat ccagggattt tttgccaggt ggtaggagag attatacagt ccaagttcag ttgagacttt gcctggcaga gacaagttgc cctcaagaag ataactatcc aaatagtcta tgtataaaag taaatgggaa gctatttcct ttgcctggct atgcaccacc gcctaaaaat gggattgaac agaagcgccc tggacgcccc ttgaatatta catctttagt taggttatct tcagctgtgc caaaccaaat ttccatttct tgggcatcag aaattgggaa gaattactct atgtctgtat atcttgtacg gcagcttaca tcagccatgt tattacagag attaaaaatg aaaggtatta gaaaccctga tcattccaga gcactaatta aagaaaaact tactgcagat cctgatagtg aaattgctac aactagcctt cgggtatcct tgatgtgccc tttaggaaaa atgaggctga caatcccatg ccgtgcagtg acttgtacac atctgcagtg ttttgatgct gccctctatc tacaaatgaa tgagaaaaag cccacctgga tttgtcctgt gtgtgacaaa aaagctgcct atgaaagtct aatattagat gggcttttta tggaaattct caatgactgt tctgatgtag atgagatcaa attccaagaa gatggttctt ggtgtccaat gagaccgaag aaagaagcta tgaaagtatc cagccaaccg tgtacaaaaa tagaaagttc aagcgtcctc agtaagcctt gttcagtgac tgtagccagt gaggcaagca agaagaaagt agatgttatt gatcttacaa tagaaagctc ttctgacgaa gaggaagacc ctcctgccaa aaggaaatgc atctttatgt cagaaacaca aagcagccca accaaagggg ttctcatgta tcagccatct tctgtaaggg tgcccagtgt gacttcggtt gatcctgctg ctattccgcc ttcattaaca gactactcag taccattcca ccatacgcca atatcaagca tgtcatcaga tttgccagga gaacaaagaa gaaatgatat taataatgaa ctgaagcttg gaacatcttc tgatactgtg caacagtga. It is sometimes possible for the material contained within the vial of "PIAS2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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