PHF12 cdna clone
PHF12 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
PHF12: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleoplasm; nucleus; Sin3 complex; transcriptional repressor complex
Molecular Function: chromatin binding; histone binding; phosphoinositide binding; protein binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Product Notes
The PHF12 phf12 (Catalog #AAA1268111) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTGGGAGA AAATGGAGAC CAAGACGATC GTGTACGACT TGGACACATC AGGGGGGCTG ATGGAGCAAA TCCAAGCTCT GCTGGCTCCC CCCAAGACGG ACGAGGCAGA AAAGCGCAGT CGGAAGCCTG AGAAGGAGCC CCGGAGAAGC GGCAGGGCCA CCAACCACGA CAGCTGCGAT AGCTGCAAGG AAGGTGGAGA TCTCCTGTGC TGCGACCACT GCCCGGCTGC CTTCCACCTC CAGTGCTGTA ACCCTCCACT GAGTGAAGAA ATGTTGCCTC CTGGAGAGTG GATGTGTCAC CGGTGCACTG TTCGCCGAAA GAAACGAGAG CAGAAAAAGG AGCTGGGTCA TGTCAATGGA CTGGTGGACA AATCTGGCAA ACGGACTACA TCCCCCAGCA GTGACACTGA CTTGTTGGAC AGATCGGCCA GCAAAACTGA ACTAAAGGCC ATTGCCCATG CCCGGATCCT GGAAAGGAGA GCCAGCAGGC CTGGCACACC CACATCCAGC GCCAGCACAG AGACTCCCAC CTCTGAGCAG AATGATGTCG ACGAAGACAT CATTGACGTG GATGAGGAAC CAGTAGCAGC GGAGCCAGAC TATGTGCAGC CCCAGCTGAG GCGGCCCTTT GAGCTGCTGA TTGCTGCCGC CATGGAGCGG AACCCCACCC AATTTCAGTT GCCCAATGAA CTGACTTGTA CCACTGCACT ACCAGGTTCT AGCAAGAGGA GAAGAAAGGA GGAAACCACA GGGAAAAATG TTAAGAAGAC ACAGCATGAA TTAGATCACA ATGGTCTCGT TCCCTTACCC GTCAAAGTCT GCTTCACGTG TAACAGGAGT TGCCGTGTGG CTCCTCTCAT CCAGTGTGAC TATTGCCCTC TCCTGTTTCA CATGGATTGC CTCGAGCCGC CGCTCACTGC CATGCCCCTG GGCAGATGGA TGTGTCCGAA TCACATCGAA CATGTGGTGC TGAACCAGAA GAATATGACA CTGAGCAATC GGTGCCAGGT GTTTGATCGT TTCCAGGACA CCGTTTCGCA GCATGTCGTC AAAGTGGACT TCCTGAACCG AATCCACAAG AAGCACCCCC CTAACCGGCG TGTGCTCCAG TCGGTCAAAA GAAGAAGCTT GAAGGTTCCT GATGCTATAA AATCTCAGTA CCAGTTTCCA CCCCCTCTCA TTGCACCCGC GGCCATTCGG GACGGGGAGC TGATCTGCAA TGGGATCCCT GAGGAATCAC AGATGCACCT TTTGAACTCT GAGCACTTAG CCACCCAAGC AGAGCAGCAA GAGTGGCTCT GTAGTGTTGT TGCGCTCCAG TGCAGCATAT TGAAACATTT ATCTGCTAAG CAGATGCCTT CGCATTGGGA CTCTGAACAG ACAGAGAAGG CTGATATTAA GCCTGTTATT GTGACTGACA GCTCAGTCAC CACCTCCCTG CAAACAGCTG ACAAGACACC TACACCTTCC CACTACCCCT TGTCCTGCCC CTCAGGGATT AGCACCCAGA ATTCCCTGAG CTGCTCTCCA CCCCACCAGT CCCCAGCCCT AGAGGACATC GGCTGCAGTT CTTGTGCGGA AAAATCCAAG AAAACCCCTT GTGGGACTGC CAATGGGCCA GTGAACACAG AGGTGAAAGC TAATGGCCCA CACCTCTACA GCAGCCCTAC TGATTCCACG GACCCCCGGC GACTTCCAGG CGCTAACACC CCACTACCAG GCCGCTCACA CCGGCAAGGC TGGCCCCGGC CCCTCACGCC ACCAGCGGCT GGGGGCCTTC AGAACCACAC CGTCGGCATC ATTGTGAAGA CAGAGAATGC CACTGGCCCC AGCTCTTGCC CCCAGAGGAG TTTGGTTCCT GTCCCAAGCC TGCCCCCTTC CATTCCCAGC TCTTGTGCCA GCATCGAGAA CACCAGCACT TTGCAAAGAA AGACTGTCCA ATCACAGATA GGACCTCCGT TGACAGATTC AAGGCCACTG GGCTCACCCC CAAACGCCAC CCGGGTGCTC ACTCCCCCGC AAGCAGCAGG AGATGGTATC TTGGCCACAA CAGCCAACCA ACGATTCAGC TCACCAGCGC CATCGTCAGG TGAGTGCTGC TCAGCCTTGG GTTGA. It is sometimes possible for the material contained within the vial of "PHF12, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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