NCOA5 cdna clone
NCOA5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
NCOA5: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: actin cytoskeleton; extracellular space; nucleus
Molecular Function: protein binding
Research Articles on NCOA5
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Product Notes
The NCOA5 ncoa5 (Catalog #AAA1271158) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccggga tgcccgggac agcagagaca ttcgagaccc ccgagacttg cgggaccaca gacatgagag actcccgaga tcctatgtac aggagagaag gctcttatga ccgataccta cgaatggatg actattgcag gagaaaggat gactcttatt ttgaccgtta cagagatagc tttgatggac ggggccctcc aggcccagaa agtcagtctc gtgcaaaaga gcgtttgaaa cgtgaggaac ggcgtagaga agagctttat cgtcaatatt ttgaggaaat ccagagacgc tttgatgccg aaaggcccgt tgattgttct gtgattgtgg tcaacaaaca gacaaaagac tatgctgagt ctgtggggcg gaaggtgcga gacctgggca tggtagtgga cttgatcttc cttaacacag aagtgtcact gtcacaagcc ttggaggatg ttagcagggg aggttctcct tttgctattg tcatcaccca gcaacaccag attcaccgct cctgcacagt caacatcatg tttggaaccc cgcaagagca tcgcaacatg ccccaagcag atgccatggt gctggtggcc agaaattatg agcgttacaa gaatgagtgc cgggagaagg aacgtgagga gattgccaga caggcagcca agatggccga tgaagccatc ctgcaggaaa gagagagagg aggccctgag gagggagtgc gtgggggcca ccctccagcc atccagagcc tcatcaacct gctggcagac aacaggtacc tcactgctga agagactgac aagatcatca actacctgcg agagcggaag gagcggctga tgaggagcag caccgactct ctgcctggtg agctacgtgg cagggccgag gcccgatttc ccgccaacca ctcggggcga cctcgggtgc ctcgctga. It is sometimes possible for the material contained within the vial of "NCOA5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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