JARID2 cdna clone
JARID2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Uniprot Description
JARID2: a Polycomb protein required for neural tube formation. Contains a Jumonji C domain but lacks histone demethylase activity. Essential for normal heart development and function. Required for embryonic viability. Down-regulation of Jarid2 impairs ES cell differentiation and Oct4 silencing. Associates with the Polycomb-Repressive Complex 2 (PRC2), stimulating PRC2 methyltransferase activity. PRC2 includes the histone H3 Lys 27 (H3K27) methyltransferase Ezh2, EED, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The recruitment of PRC2 to a promoter leads to increased levels of di- and trimethylation of H3K27 (H3K27me2/3), regulating the balance between self-renewal and differentiation of embryonic stem cells. The ability of Jarid 2 to be recruited to DNA in ES cells is interdependent on PRC2. Its knockdown reduces PRC2 at its target promoters, while ES cells lacking the PRC2 component EED are deficient in Jarid2 promoter activity. Acts as a transcriptional repressor of ANF by binding to both GATA4 and NKX2-5 and repressing their transcriptional activator activities. Participates in the negative regulation of cell proliferation signaling. Interacts with the N-terminal region of GATA4 and the C- terminal region of the NKX2-5 homeobox and represses their ability to activate transcription of ANF.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6p24-p23
Cellular Component: ESC/E(Z) complex; histone methyltransferase complex; nucleoplasm; nucleus
Molecular Function: chromatin binding; histone demethylase activity
Biological Process: central nervous system development; negative regulation of gene expression, epigenetic; negative regulation of histone methylation; negative regulation of transcription, DNA-dependent; positive regulation of histone H3-K9 methylation; stem cell differentiation
Research Articles on JARID2
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Product Notes
The JARID2 jarid2 (Catalog #AAA1268032) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGCAAGG AAAGACCCAA GAGGAATATC ATTCAGAAGA AATACGATGA CAGTGATGGG ATTCCGTGGT CAGAAGAACG GGTGGTACGT AAAGTCCTTT ATTTGTCTCT GAAGGAGTTC AAGAATTCCC AGAAGAGGCA GCATGCGGAA GGCATTGCTG GGAGCCTGAA AACTGTGAAT GGGCTCCTTG GTAATGACCA GTCTAAGGGA TTAGGACCAG CATCAGAACA GTCAGAGAAT GAAAAGGACG ATGCATCCCA AGTGTCCTCC ACTAGCAACG ATGTTAGTTC TTCAGATTTT GAAGAAGGGC CGTCGAGGAA AAGGCCCAGG CTGCAAGCAC AAAGGAAGTT TGCTCAGTCT CAGCCGAATA GTCCCAGCAC AACTCCAGTA AAGATAGTGG AGCCATTGCT ACCCCCTCCA GCTACTCAGA TATCAGACCT CTCTAAAAGG AAGCCTAAGA CAGAAGATTT TCTTACCTTT CTCTGCCTTC GAGGTTCTCC TGCGCTGCCC AACAGCATGG TGTATTTTGG AAGCTCTCAG GATGAGGAGG AAGTCGAGGA GGAAGATGAT GAGACAGAAG ACGTCAAAAC AGCCACCAAC AATGCTTCAT CTTCATGCCA GTCGACCCCC AGGAAAGGAA AAACCCACAA ACATGTTCAC AACGGGCATG TTTTCAATGG TTCCAGCAGG TCAACACGGG AGAAGGAACC TGTTCAAAAA CACAAAAGCA AAGAGGCCAC TCCCGCAAAG GAGAAGCACA GCGATCACCG GGCTGACAGC CGCCGGGAGC AGGCTTCAGC TAACCACCCC GCAGCGGCCC CCTCCACGGG TTCCTCGGCC AAGGGGCTTG CTGCCACCCA TCACCACCCC CCTCTGCATC GGTCGGCTCA GGACTTACGG AAACAGGTTT CTAAGGTAAA CGGAGTCACT CGAATGTCAT CTCTGGGTGC AGGTGTAACC AGTGCCAAAA AGATGCGCGA GGTCAGACCT TCACCATCCA AAACTGTGAA GTACACTGCC ACGGTGACGA AGGGGGCTGT CACATACACC AAAGCCAAGA GAGAACTGGT CAAGGACACC AAACCCAATC ACCACAAGCC CAGTTCCGCT GTCAACCACA CAATCTCAGG GAAAACTGAA AGTAGCAATG CAAAAACCCG CAAACAGGTG CTATCCCTCG GGGGGGCGTC CAAGTCCACT GGGCCCGCCG TCAATGGCCT CAAGGTCAGT GGCAGGTTGA ACCCAAAGTC ATGCACTAAG GAGGTGGGGG GGCGGCAGCT GCGGGAGGGC CTGCAGCTGC GGGAGGGGCT GCGGAACTCC AAGAGGAGAC TGGAAGAGGC ACACCAGGCG GAGAAGCCGC AGTCGCCCCC CAAGAAGATG AAAGGGGCGG CTGGCCCCGC CGAAGGCCCT GGCAAGAAGG CCCCGGCCGA GAGAGGTCTG CTGAACGGAC ACGTGAAGAA GGAAGTGCCG GAGCGCAGTC TGGAGAGGAA TCGGCCGAAG CGGGCCACGG CCGGGAAGAG CACGCCAGGC AGACAAGCAC ATGGCAAGGC GGACAGCGCC TCCTGTGAAA ATCGTTCTAC CTCGCAACCG GAGTCCGTGC ACAAGCCGCA GGACTCGGGC AAGGCCGAGA AGGGCGGCGG CAAGGCCGGG TGGGCGGCCA TGGACGAGAT CCCCGTCCTC AGGCCCTCCG CCAAGGAGTT CCACGATCCG CTCATCTACA TCGAGTCGGT CCGCGCTCAG GTGGAGAAGT TCGGGATGTG CAGGGTGATC CCCCCTCCGG ACTGGCGGCC CGAGTGCAAG CTCAACGATG AGATGCGGTT TGTCACGCAG ATTCAGCACA TCCACAAGCT GGGCCGGCGC TGGGGCCCCA ACGTGCAGCG GCTGGCCTGC ATCAAGAAGC ACCTCAAATC TCAGGGCATC ACCATGGACG AGCTCCCGCT CATAGGGGGC TGTGAGCTCG ACCTGGCCTG CTTTTTCCGG CTGATTAATG AGATGGGCGG CATGCAGCAA GTGACTGACC TCAAAAAATG GAACAAACTA GCAGACATGC TGCGCATCCC CAGAACTGCC CAGGACCGGC TGGCCAAGCT GCAGGAGGCC TACTGCCAGT ACCTACTCTC CTACGACTCC CTGTCCCCAG AGGAGCACCG GCGGCTGGAG AAGGAGGTGC TGATGGAGAA GGAGATCCTG GAGAAGCGCA AGGGGCCGCT GGAAGGCCAC ACAGAGAACG ACCACCACAA GTTCCACCCT CTGCCCCGCT TCGAGCCCAA GAATGGGCTC ATCCACGGCG TGGCCCCCAG GAACGGCTTC CGCAGCAAGC TCAAGGAGGT GGGCCAGGCC CAGTTGAAGA CTGGCCGGCG GCGACTCTTC GCTCAGGAAA AAGAAGTGGT CAAGGAAGAG GAGGAGGACA AAGGCGTCCT CAATGACTTC CACAAGTGCA TCTATAAGGG AAGGTCTGTT TCTCTAACAA CTTTTTATCG AACAGCGAGG AATATCATGA GCATGTGTTT CAGCAAGGAG CCTGCCCCAG CCGAAATCGA GCAAGAGTAC TGGAGGCTAG TGGAAGAGAA GGACTGCCAC GTGGCAGTGC ACTGCGGCAA GGTGGACACC AACACTCACG GCAGTGGATT CCCAGTAGGA AAATCAGAAC CCTTTTCGAG GCATGGATGG AACCTCACCG TCCTCCCCAA TAACACAGGG TCCATCCTGC GTCACCTCGG TGCTGTGCCT GGAGTGACTA TTCCCTGGCT AAATATTGGC ATGGTCTTTT CTACCTCATG CTGGTCTCGA GACCAAAATC ACCTTCCATA CATTGACTAC TTACACACTG GTGCTGACTG CATTTGGTAT TGCATTCCTG CTGAGGAGGA GAACAAGCTG GAAGATGTGG TCCACACCCT GCTGCAAGCC AATGGCACCC CAGGGCTGCA GATGCTGGAA AGCAACGTCA TGATCTCCCC GGAGGTGCTG TGCAAAGAGG GGATCAAGGT GCACAGGACC GTGCAGCAGA GTGGCCAGTT TGTCGTCTGC TTCCCGGGAT CCTTTGTGTC CAAAGTGTGC TGTGGGTACA GCGTGTCTGA AACCGTGCAC TTTGCTACCA CCCAGTGGAC AAGTATGGGC TTTGAGACCG CCAAGGAAAT GAAGCGTCGC CATATAGCTA AGCCATTCTC CATGGAGAAG TTACTCTACC AGATTGCACA AGCAGAAGCA AAAAAAGAAA ACGGTCCCAC TCTCAGTACC ATCTCAGCCC TCCTGGATGA GCTCAGGGAT ACAGAGCTGC GGCAGCGCAG GCAGCTGTTC GAGGCTGGCC TCCACTCCTC CGCACGCTAT GGCAGCCACG ATGGCAGCAG CACGGTGGCG GACGGGAAGA AAAAGCCTCG AAAGTGGCTG CAGTTGGAGA CGTCAGAGAG GAGGTGTCAG ATCTGCCAGC ACCTGTGCTA CCTGTCCATG GTGGTACAAG AGAACGAAAA CGTCGTGTTC TGTCTGGAGT GTGCTCTGCG CCACGTGGAG AAACAGAAGT CCTGCCGAGG GCTGAAGTTG ATGTACCGCT ACGATGAGGA ACAGATTATC AGTCTGGTCA ATCAGATCTG CGGCAAAGTG TCTGGTAAAA ACGGCAGCAT TGAGAACTGT CTCAGTAAAC CCACACCAAA AAGAGGTCCC CGCAAGAGAG CGACAGTGGA CGTGCCCCCC TCCCGTCTGT CAGCCTCCAG TTCATCCAAA AGTGCTTCGA GCTCATCATG A. It is sometimes possible for the material contained within the vial of "JARID2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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